Plasma growth hormone pattern and androgens influence the levels of corticosteroid-binding globulin in rat serum
- PMID: 2809480
- DOI: 10.1677/joe.0.1220725
Plasma growth hormone pattern and androgens influence the levels of corticosteroid-binding globulin in rat serum
Abstract
The serum concentration of corticosteroid-binding globulin (CBG) is higher in female rats than in males. Combined hypophysectomy and gonadectomy of female rats reduced the serum concentration of CBG as measured by steady-state polyacrylamide gel electrophoresis, whereas hypophysectomy of male rats increased serum CBG. These effects were seen despite replacement therapy with thyroxine and glucocorticoids. Moreover, neither androgen nor oestrogen treatment affected the serum concentrations of CBG in hypophysectomized rats. Continuous infusions of human or bovine GH (1.4 U/kg per day), by means of osmotic minipumps for 1 week, increased serum concentrations of CBG in both hypophysectomized male and female rats. In contrast, intermittent GH replacement therapy by s.c. injections at 12-h intervals either had no effect or suppressed serum CBG levels. In male rats, neonatal (days 1-2) gonadectomy increased CBG levels more than did prepubertal (day 25) gonadectomy, and testosterone replacement therapy reversed these effects. It is concluded that GH increases the serum CBG levels of hypophysectomized rats when it is given in a continuous manner, but not when given intermittently. The sex difference in serum CBG levels of normal rats may, therefore, be attributed to the more continuous secretory pattern of GH previously observed in female rats.
Similar articles
-
Influence of gonadal steroids on age- and sex-related secretory patterns of growth hormone in the rat.Endocrinology. 1984 Apr;114(4):1287-94. doi: 10.1210/endo-114-4-1287. Endocrinology. 1984. PMID: 6705738
-
Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor I and liver GH receptors in hypophysectomized rats.Endocrinology. 1988 Aug;123(2):1053-9. doi: 10.1210/endo-123-2-1053. Endocrinology. 1988. PMID: 3396497
-
[Mechanisms of sex differentiation of the level of corticosteroid-binding globulin in rats].Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):66-70. Probl Endokrinol (Mosk). 1988. PMID: 3237669 Russian.
-
Differential effects of continuous versus intermittent administration of growth hormone to hypophysectomized female rats on serum lipoproteins and their apoproteins.Endocrinology. 1989 Sep;125(3):1638-49. doi: 10.1210/endo-125-3-1638. Endocrinology. 1989. PMID: 2759036
-
Sexual dimorphism in the control of growth hormone secretion.Endocr Rev. 1985 Spring;6(2):128-50. doi: 10.1210/edrv-6-2-128. Endocr Rev. 1985. PMID: 2861084 Review.
Cited by
-
Sex-specific maternal programming of corticosteroid-binding globulin by predator odour.Proc Biol Sci. 2021 Dec 8;288(1964):20211908. doi: 10.1098/rspb.2021.1908. Epub 2021 Dec 1. Proc Biol Sci. 2021. PMID: 34847769 Free PMC article.
-
Sexual Dimorphism in Glucocorticoid Stress Response.Int J Mol Sci. 2021 Mar 19;22(6):3139. doi: 10.3390/ijms22063139. Int J Mol Sci. 2021. PMID: 33808655 Free PMC article. Review.
-
New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.PLoS One. 2016 Jan 7;11(1):e0146497. doi: 10.1371/journal.pone.0146497. eCollection 2016. PLoS One. 2016. PMID: 26741814 Free PMC article.
-
Somatostatin is essential for the sexual dimorphism of GH secretion, corticosteroid-binding globulin production, and corticosterone levels in mice.Endocrinology. 2015 Mar;156(3):1052-65. doi: 10.1210/en.2014-1429. Epub 2014 Dec 31. Endocrinology. 2015. PMID: 25551181 Free PMC article.
-
Size at birth, morning cortisol and cardiometabolic risk markers in healthy Indian children.Clin Endocrinol (Oxf). 2014 Jan;80(1):73-9. doi: 10.1111/cen.12143. Epub 2013 Jul 2. Clin Endocrinol (Oxf). 2014. PMID: 23297873 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous