The analgesic effects of oxytocin in the peripheral and central nervous system
- PMID: 28065792
- DOI: 10.1016/j.neuint.2016.12.021
The analgesic effects of oxytocin in the peripheral and central nervous system
Abstract
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species often caused by actual and potential tissue damage. However, it is absolutely crucial for our survival in many ways. Acute pain can signal the presence of danger or life-threatenting events, which help escape noxious stimuli. By contrast, when pain becomes chronic or persistent, it becomes an encumbrance and exerts deleterious effects to the body and mind, often co-occured with anxiety and depression. Additionaly, chronic pain is more or less an economic burden for the patients because it requires immediate medical treatments and seriously hinders pepople in their work. To date, there has been a lack of breakthrough progress in the pain field, despite huge gains in basic science knowledge obtained using animal models, it is still difficult to develop many new clinically effective analgesic drugs to control pain with long-term effectiveness. Opioids and nonsteroidal anti-inflammatory drugs were introduced for pain management more than a century ago. Those drugs do have proven efficacy in the treatment of pain but the use of them are also significantly limited due to the multiple serious adverse effects (e.g., drug resistance, addiction and gastrointestinal bleeding). In the field of pain relief and treatment, there is a strong impetus to develop and establish novel analgesics that must be safer and more effective to offer significant pain relief for a wide variety of painful conditions. Preliminary evidence suggests that oxytocin might be the ideal candidate as a target for reducing the severity of pain. In this review, we present a summary of the total literature related to the effects of oxytocin on pain modulation in both animals and humans. Better understanding the fundamental physiopharmacology of the actions of oxytocin in pain may highlight novel mechanisms associated with analgesia.
Keywords: Analgesia; Antinociceptive; Oxytocin; Pain.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
-
Oxytocin and the modulation of pain experience: Implications for chronic pain management.Neurosci Biobehav Rev. 2015 Aug;55:53-67. doi: 10.1016/j.neubiorev.2015.04.013. Epub 2015 May 5. Neurosci Biobehav Rev. 2015. PMID: 25956252 Review.
-
Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain condition.Pain Physician. 2013 May-Jun;16(3):E199-216. Pain Physician. 2013. PMID: 23703419 Clinical Trial.
-
Opioids, sensory systems and chronic pain.Eur J Pharmacol. 2013 Sep 15;716(1-3):179-87. doi: 10.1016/j.ejphar.2013.01.076. Epub 2013 Mar 13. Eur J Pharmacol. 2013. PMID: 23500206 Review.
-
Adverse effects associated with non-opioid and opioid treatment in patients with chronic pain.Clin Drug Investig. 2012 Feb;32 Suppl 1:53-63. doi: 10.2165/11630080-000000000-00000. Clin Drug Investig. 2012. PMID: 23389876 Review.
-
Pharmacological approaches other than opioids in chronic non-cancer pain management.Acta Anaesthesiol Scand. 1997 Jan;41(1 Pt 2):187-90. doi: 10.1111/j.1399-6576.1997.tb04636.x. Acta Anaesthesiol Scand. 1997. PMID: 9061105
Cited by
-
Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.bioRxiv [Preprint]. 2024 May 14:2024.05.13.593981. doi: 10.1101/2024.05.13.593981. bioRxiv. 2024. PMID: 38798601 Free PMC article. Preprint.
-
Considerations for hormonal therapy in migraine patients: a critical review of current practice.Expert Rev Neurother. 2023 Dec 19;24(1):1-21. doi: 10.1080/14737175.2023.2296610. Online ahead of print. Expert Rev Neurother. 2023. PMID: 38112066 Free PMC article. Review.
-
The Association of Reproductive Hormones During the Menstrual Period with Primary Dysmenorrhea.Int J Womens Health. 2023 Oct 9;15:1501-1514. doi: 10.2147/IJWH.S421950. eCollection 2023. Int J Womens Health. 2023. PMID: 37840555 Free PMC article.
-
Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice.CNS Neurosci Ther. 2023 Nov;29(11):3493-3506. doi: 10.1111/cns.14282. Epub 2023 May 29. CNS Neurosci Ther. 2023. PMID: 37248645 Free PMC article.
-
Revisiting oxytocin generation in keratinocytes.Biophys Physicobiol. 2023 Jan 14;20(1):e200003. doi: 10.2142/biophysico.bppb-v20.0003. eCollection 2023. Biophys Physicobiol. 2023. PMID: 37234847 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical