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Review
. 2016 Sep 22;6(3):283-93.
doi: 10.5498/wjp.v6.i3.283.

Neuroinflammation and cytokine abnormality in major depression: Cause or consequence in that illness?

Sang Won Jeon  1 , Yong Ku Kim  1
Affiliations
Review

Neuroinflammation and cytokine abnormality in major depression: Cause or consequence in that illness?

Sang Won Jeon et al. World J Psychiatry. .

Abstract

Depression results from changes in the central nervous system (CNS) that may result from immunological abnormalities. The immune system affects the CNS through cytokines, which regulate brain activities and emotions. Cytokines affect two biological systems that are most associated with the pathophysiology of depression: The hypothalamic-pituitary-adrenal axis and the catecholamine/sympathetic nervous system. Neuroinflammation and cytokines affect the brain signal patterns involved in the psychopathology of depression and the mechanisms of antidepressants, and they are associated with neurogenesis and neural plasticity. These observations suggest that neuroinflammation and cytokines might cause and/or maintain depression, and that they might be useful in the diagnosis and prognosis of depression. This psychoneuroimmunologic perspective might compensate for some of the limitations of the monoamine theory by suggesting that depression is a result of a failure to adapt to stress and that inflammatory responses and cytokines are involved in this process. In this review, the interactions of cytokines with the CNS, neuroendocrine system, neurotransmitters, neurodegeneration/neurogenesis, and antidepressants are discussed. The roles of cytokines in the etiology and psychopathology of depression are examined. The use of cytokine inhibitors or anti-inflammatory drugs in depression treatment is explored. Finally, the significance and limitations of the cytokine hypothesis are discussed.

Keywords: Antidepressant; Cytokine; Depression; Neuroendocrine; Neurogenesis; Neuroinflammation; Neurotransmitter; Psychoneuroimmunology.

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Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest. No financial support.

Figures

Figure 1
Figure 1
The role of cytokine network in depression in connection with immune system, hypothalamic-pituitary-adrenal axis, neurotransmitter, and autonomic nerve system. The figure shows communication between peripheral and central cytokine system. Early innate proinflammatory cytokines released by macrophage (TNF-α, IL-1, IL-6 and INF-α), and late acquired T cell cytokines (IL-2 and INF-γ) stimulate glucocorticoid secretion by acting at all three levels of the HPA axis. Glucocorticoids are negatively feedback on the peripheral immune system to suppress the production of proinflammatory cytokines. Glucocorticoids also play an important role in causing a shift from cellular (T-helper 1) to humoral (T-helper 2) immune responses. The central cytokines are usually secreted from the astrocyte or microglia. Central cytokines (IL-1, IL-6, TNF-α, and IFN-γ) are considered to be involved in neuroplasticity in brain. The neurotransmitters (NA, ACH, and 5-HT) regulate the peripheral cytokines by changing the cortisol concentration level. The Ach, DA, and NA promote the secretion of the CRH in hypothalamus, and 5-HT inhibits the secretion of the CRH in hypothalamus and the ACTH in pituitary. The ANS also regulates the peripheral cytokine production. The parasympathetic nerve directly reaches the immune system while the sympathetic nerve affects the immune system through the NA secretion from the peripheral sympathetic ganglia. 5-HT: Serotonin; ACH: Acetylcholine; ACTH: Adrenocorticotropic hormone; ANS: Autonomic nerve system; CRH: Corticotropin-releasing factor; DA: Dopamine; HPA: Hypothalamic-pituitary-adrenal; NA: Noradrenalin; PVN: Paraventricular nucleus of the hypothalamus; TH: Helper T cell; IL: Interleukins; TNF: Tumor necrosis factor; IFN: Interferons.
Figure 2
Figure 2
Schematic representation of neuroinflammatory pathways in the pathogenesis of depression. Cytokine production is initially activated by stress and sympathetic nerve system activation. In turn, cytokines have an important role by acting via neurotransmitter depletion pathway, neuroendocrine pathway, and neural plasticity pathway. There are multiple interactions between these pathways suggesting existence of a complex model for pathogenesis of depression. 5-HT: Serotonin; BDNF: Brain derived neurotrophic factor; GR: Glucocorticoid receptor; HPA: Hypothalamic-pituitary-adrenal; IDO: Indoleamine-2,3-dioxygenase; NMDA: N-methyl-D-aspartate.
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