Review

. 2016 Nov;27(11):782-795.

doi: 10.1016/j.tem.2016.06.008. Epub 2016 Jul 18.

The Emerging Role of Epigenetics in Inflammation and Immunometabolism

Sukanya Raghuraman¹, Ida Donkin², Soetkin Versteyhe², Romain Barrès³, David Simar⁴

Affiliations

¹ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia.
² The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
³ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁴ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: d.simar@unsw.edu.au.

PMID: 27444065
DOI: 10.1016/j.tem.2016.06.008

Review

The Emerging Role of Epigenetics in Inflammation and Immunometabolism

Sukanya Raghuraman et al. Trends Endocrinol Metab. 2016 Nov.

. 2016 Nov;27(11):782-795.

doi: 10.1016/j.tem.2016.06.008. Epub 2016 Jul 18.

Authors

Sukanya Raghuraman¹, Ida Donkin², Soetkin Versteyhe², Romain Barrès³, David Simar⁴

Affiliations

¹ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia.
² The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
³ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁴ Inflammation and Infection Research, School of Medical Sciences, University of New South Wales, Sydney, Australia; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: d.simar@unsw.edu.au.

PMID: 27444065
DOI: 10.1016/j.tem.2016.06.008

Abstract

Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

Keywords: epigenetics; immune system; inflammation; metabolic diseases; obesity.

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The Emerging Role of Epigenetics in Inflammation and Immunometabolism

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The Emerging Role of Epigenetics in Inflammation and Immunometabolism

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