Epigenetic balance of gene expression by Polycomb and COMPASS families
- PMID: 27257261
- DOI: 10.1126/science.aad9780
Epigenetic balance of gene expression by Polycomb and COMPASS families
Abstract
Epigenetic regulation of gene expression in metazoans is central for establishing cellular diversity, and its deregulation can result in pathological conditions. Although transcription factors are essential for implementing gene expression programs, they do not function in isolation and require the recruitment of various chromatin-modifying and -remodeling machineries. A classic example of developmental chromatin regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 complexes, and the Trithorax group (TrxG) proteins within the COMPASS family, which are highly mutated in a large number of human diseases. In this review, we will discuss the latest findings regarding the properties of the PcG and COMPASS families and the insight they provide into the epigenetic control of transcription under physiological and pathological settings.
Copyright © 2016, American Association for the Advancement of Science.
Similar articles
-
COMPASS and SWI/SNF complexes in development and disease.Nat Rev Genet. 2021 Jan;22(1):38-58. doi: 10.1038/s41576-020-0278-0. Epub 2020 Sep 21. Nat Rev Genet. 2021. PMID: 32958894 Review.
-
Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.Nucleic Acids Res. 2016 Dec 1;44(21):10132-10149. doi: 10.1093/nar/gkw701. Epub 2016 Aug 23. Nucleic Acids Res. 2016. PMID: 27557709 Free PMC article.
-
An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS.Mol Cell. 2016 Jul 21;63(2):318-328. doi: 10.1016/j.molcel.2016.06.018. Mol Cell. 2016. PMID: 27447986 Free PMC article.
-
Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.PLoS Genet. 2015 Dec 7;11(12):e1005660. doi: 10.1371/journal.pgen.1005660. eCollection 2015 Dec. PLoS Genet. 2015. PMID: 26642436 Free PMC article.
-
Recruiting polycomb to chromatin.Int J Biochem Cell Biol. 2015 Oct;67:177-87. doi: 10.1016/j.biocel.2015.05.006. Epub 2015 May 14. Int J Biochem Cell Biol. 2015. PMID: 25982201 Free PMC article. Review.
Cited by
-
Unveiling the Molecular Landscape of Pancreatic Ductal Adenocarcinoma: Insights into the Role of the COMPASS-like Complex.Int J Mol Sci. 2024 May 7;25(10):5069. doi: 10.3390/ijms25105069. Int J Mol Sci. 2024. PMID: 38791111 Free PMC article. Review.
-
Developmental origins shape the paediatric cancer genome.Nat Rev Cancer. 2024 Jun;24(6):382-398. doi: 10.1038/s41568-024-00684-9. Epub 2024 May 2. Nat Rev Cancer. 2024. PMID: 38698126 Review.
-
Transient loss of Polycomb components induces an epigenetic cancer fate.Nature. 2024 May;629(8012):688-696. doi: 10.1038/s41586-024-07328-w. Epub 2024 Apr 24. Nature. 2024. PMID: 38658752 Free PMC article.
-
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma.Clin Epigenetics. 2024 Apr 10;16(1):54. doi: 10.1186/s13148-024-01666-2. Clin Epigenetics. 2024. PMID: 38600608 Free PMC article. Review.
-
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor.Mol Psychiatry. 2024 Mar 26. doi: 10.1038/s41380-024-02479-8. Online ahead of print. Mol Psychiatry. 2024. PMID: 38528071
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases