The Nuclear Receptor Superfamily at Thirty
- PMID: 27246330
- DOI: 10.1007/978-1-4939-3724-0_1
The Nuclear Receptor Superfamily at Thirty
Abstract
The human genome codes for 48 members of the nuclear receptor superfamily, half of which have known ligands. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins, and prostaglandins. Nuclear receptors regulate gene expression programs controlling development, differentiation, metabolic homeostasis and reproduction, in both a temporal and a tissue-selective manner. Since the original cloning of the cDNAs for the estrogen and glucocorticoid receptors, large strides have been made in our understanding of the structure and function of this family of transcription factors and their role in pathophysiology.
Keywords: Allosteric regulation; Gene expression; Nuclear receptors; Steroid hormones.
Similar articles
-
Nuclear receptors: one big family.Methods Mol Biol. 2009;505:3-18. doi: 10.1007/978-1-60327-575-0_1. Methods Mol Biol. 2009. PMID: 19117136 Review.
-
Bile salt excretory pump: biology and pathobiology.J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S10-6. doi: 10.1097/01.mpg.0000226385.71859.5f. J Pediatr Gastroenterol Nutr. 2006. PMID: 16819395 Review.
-
Sex, drugs and gene expression: signalling by members of the nuclear receptor superfamily.Essays Biochem. 2004;40:1-10. doi: 10.1042/bse0400001. Essays Biochem. 2004. PMID: 15242335 Review.
-
Steroidogenic factor-1: its role in endocrine organ development and differentiation.Front Neuroendocrinol. 1999 Jul;20(3):199-223. doi: 10.1006/frne.1999.0182. Front Neuroendocrinol. 1999. PMID: 10433862 Review.
-
A regulatory role for RIP140 in nuclear receptor activation.Mol Endocrinol. 1998 Jun;12(6):864-81. doi: 10.1210/mend.12.6.0123. Mol Endocrinol. 1998. PMID: 9626662
Cited by
-
Gene transcription regulation by ER at the single cell and allele level.Steroids. 2023 Dec;200:109313. doi: 10.1016/j.steroids.2023.109313. Epub 2023 Sep 25. Steroids. 2023. PMID: 37758052
-
Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia.Cells. 2020 Aug 19;9(9):1921. doi: 10.3390/cells9091921. Cells. 2020. PMID: 32824945 Free PMC article. Review.
-
Cross‑validation of genes potentially associated with neoadjuvant chemotherapy and platinum‑based chemoresistance in epithelial ovarian carcinoma.Oncol Rep. 2020 Sep;44(3):909-926. doi: 10.3892/or.2020.7668. Epub 2020 Jul 2. Oncol Rep. 2020. PMID: 32705213 Free PMC article.
-
The Role of ERα36 in Development and Tumor Malignancy.Int J Mol Sci. 2020 Jun 9;21(11):4116. doi: 10.3390/ijms21114116. Int J Mol Sci. 2020. PMID: 32526980 Free PMC article. Review.
-
[Research progress on the involvement of nuclear receptor in regulating autophagy].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 Oct 25;35(5):822-828. doi: 10.7507/1001-5515.201804028. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018. PMID: 30370726 Free PMC article. Review. Chinese.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
