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. 2016 Jun;141(3):588-591.
doi: 10.1016/j.ygyno.2016.04.001. Epub 2016 Apr 15.

Sequencing of mutational hotspots in cancer-related genes in small cell neuroendocrine cervical cancer

Michael Frumovitz  1 , Jennifer K Burzawa  2 , Lauren A Byers  3 , Yasmin A Lyons  2 , Preetha Ramalingam  4 , Robert L Coleman  2 , Jubilee Brown  2
Affiliations

Sequencing of mutational hotspots in cancer-related genes in small cell neuroendocrine cervical cancer

Michael Frumovitz et al. Gynecol Oncol. 2016 Jun.

Erratum in

Abstract

Objectives: Small cell cervical cancer is a rare malignancy with limited treatment options for recurrent disease. We sought to determine if tumor specimens of small cell cervical cancer harbor common somatic mutations and if any of these are actionable.

Methods: Using a registry of patients with neuroendocrine cervical cancer, we identified 44 patients with pure or mixed small cell cervical cancer who had undergone mutational analysis. Mutations had been detected using next generation sequencing of mutational hotspots in 50 cancer-related genes.

Results: Thirty-five mutations were identified in 24 patients (55%). Fifteen of these 24 patients (63%) had 1 mutation, 7 patients (29%) had 2 mutations, and 2 patients (8%) had 3 mutations. In all 44 patients, the most commonly seen mutations were mutations in PIK3CA (8 patients; 18%), KRAS (6 patients; 14%), and TP53 (5 patients; 11%). No other mutation was found in >7% of specimens. Of the 24 patients who had a mutation, 21 (88%) had at least 1 alteration for which there currently exists a class of biological agents targeting that mutation. In the entire cohort of 44 patients, 48% had at least 1 actionable mutation.

Conclusion: Although no single mutation was found in the majority of patients with small cell cervical cancer, almost half had at least 1 actionable mutation. As treatment options for patients with recurrent small cell cervical cancer are currently very limited, molecular testing for targetable mutations, which may suggest potential therapeutic strategies, may be useful for clinicians and patients.

Keywords: Cervical cancer; Large cell; Neuroendocrine; Personalized medicine; Small cell; Somatic mutations.

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Conflict of interest statement

Conflict of Interest Statement: The authors have no conflicts of interest to disclose

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