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. 2016 May;13(5):4215-20.
doi: 10.3892/mmr.2016.5052. Epub 2016 Mar 28.

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

Huimin Wang  1 , Huiling Wang  2 , Huixin Cheng  3 , Zhenyong Che  1
Affiliations

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

Huimin Wang et al. Mol Med Rep. 2016 May.

Abstract

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It is characterized by the formation of amyloid plaques and neurofibrillary tangles in the brain, the degeneration of cholinergic neurons and neuronal cell death. The present study aimed to investigate the effect of luteolin, a flavonoid compound, on memory impairment in a streptozotocin (STZ)‑induced Alzheimer's rat model. Morris water maze and probe tests were performed to examine the effect of luteolin treatment on cognition and memory. The effect of luteolin on CA1 pyramidal layer thickness was also examined. The results demonstrated that luteolin significantly ameliorated the spatial learning and memory impairment induced by STZ treatment. STZ significantly reduced the thickness of CA1 pyramidal layer and treatment of luteolin completely abolished the inhibitory effect of STZ. Our results suggest that luteolin has a potentially protective effect on learning defects and hippocampal structures in AD.

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Figures

Figure 1
Figure 1
Effect of luteolin on (A) escape latency and (B) traveled distance of the streptozotocin (STZ)-induced Alzheimer's disease rat model. *P<0.05 vs. control, ^P<0.05 vs. STZ group.
Figure 2
Figure 2
Effect of luteolin on swimming speed of the Alzheimer's disease rat model. STZ, streptozotocin.
Figure 3
Figure 3
Effect of luteolin on performance in probe test of the Alzheimer's disease rat model. *P<0.05 vs. control, ^P<0.05 vs. streptozotocin (STZ) group.
Figure 4
Figure 4
Effect of luteolin on CA1 pyramidal layer thickness of the Alzheimer's disease rat model. *P<0.05 vs. control, ^P<0.05 vs. streptozotocin (STZ) group.
See this image and copyright information in PMC

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