Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus
- PMID: 26938868
- PMCID: PMC4777396
- DOI: 10.1371/journal.pntd.0004543
Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus
Abstract
Background: Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia.
Methodology/principal findings: Mosquitoes were orally exposed to an Asian genotype of ZIKV (NC-2014-5132). Upon exposure, engorged mosquitoes were maintained at 28° ± 1 °C, a 16h:8h light:dark cycle and 80% humidity. 25-30 mosquitoes were processed at 4, 7 and 14 days post-infection (dpi). Mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination and transmission, respectively. High infection but lower disseminated infection and transmission rates were observed for both Ae. aegypti and Ae. albopictus. Ae. aegypti populations from Guadeloupe and French Guiana exhibited a higher dissemination of ZIKV than the other Ae. aegypti populations examined. Transmission of ZIKV was observed in both mosquito species at 14 dpi but at a low level.
Conclusions/significance: This study suggests that although susceptible to infection, Ae. aegypti and Ae. albopictus were unexpectedly low competent vectors for ZIKV. This may suggest that other factors such as the large naïve population for ZIKV and the high densities of human-biting mosquitoes contribute to the rapid spread of ZIKV during the current outbreak.
Conflict of interest statement
The authors have declared that no competing interests exist.
Figures
![Fig 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4777396/bin/pntd.0004543.g001.gif)
![Fig 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4777396/bin/pntd.0004543.g002.gif)
![Fig 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4777396/bin/pntd.0004543.g003.gif)
Similar articles
-
Zika Virus, a New Threat for Europe?PLoS Negl Trop Dis. 2016 Aug 9;10(8):e0004901. doi: 10.1371/journal.pntd.0004901. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27505002 Free PMC article.
-
Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus.PLoS Negl Trop Dis. 2019 Apr 4;13(4):e0007281. doi: 10.1371/journal.pntd.0007281. eCollection 2019 Apr. PLoS Negl Trop Dis. 2019. PMID: 30946747 Free PMC article.
-
Zika virus outbreak in the Pacific: Vector competence of regional vectors.PLoS Negl Trop Dis. 2018 Jul 17;12(7):e0006637. doi: 10.1371/journal.pntd.0006637. eCollection 2018 Jul. PLoS Negl Trop Dis. 2018. PMID: 30016372 Free PMC article.
-
Zika virus: An updated review of competent or naturally infected mosquitoes.PLoS Negl Trop Dis. 2017 Nov 16;11(11):e0005933. doi: 10.1371/journal.pntd.0005933. eCollection 2017 Nov. PLoS Negl Trop Dis. 2017. PMID: 29145400 Free PMC article. Review.
-
Zika Virus Mosquito Vectors: Competence, Biology, and Vector Control.J Infect Dis. 2017 Dec 16;216(suppl_10):S976-S990. doi: 10.1093/infdis/jix405. J Infect Dis. 2017. PMID: 29267910 Free PMC article. Review.
Cited by
-
Exposure to Zika and chikungunya viruses impacts aspects of the vectorial capacity of Aedes aegypti and Culex quinquefasciatus.PLoS One. 2024 May 15;19(5):e0281851. doi: 10.1371/journal.pone.0281851. eCollection 2024. PLoS One. 2024. PMID: 38748732 Free PMC article.
-
Assessing and managing the risk of Aedes mosquito introductions via the global maritime trade network.PLoS Negl Trop Dis. 2024 Apr 10;18(4):e0012110. doi: 10.1371/journal.pntd.0012110. eCollection 2024 Apr. PLoS Negl Trop Dis. 2024. PMID: 38598547 Free PMC article.
-
Increased threat of urban arboviral diseases from Aedes aegypti mosquitoes in Colombia.IJID Reg. 2024 Mar 22;11:100360. doi: 10.1016/j.ijregi.2024.100360. eCollection 2024 Jun. IJID Reg. 2024. PMID: 38596820 Free PMC article.
-
Intersecting vulnerabilities: climatic and demographic contributions to future population exposure to Aedes-borne viruses in the United States.Environ Res Lett. 2020 Aug;15(8):084046. doi: 10.1088/1748-9326/ab9141. Epub 2020 Aug 12. Environ Res Lett. 2020. PMID: 38585625 Free PMC article.
-
Mosquito ageing modulates the development, virulence and transmission potential of pathogens.Proc Biol Sci. 2024 Jan 10;291(2014):20232097. doi: 10.1098/rspb.2023.2097. Epub 2024 Jan 3. Proc Biol Sci. 2024. PMID: 38166422 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous