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. 2017 Jun;56(4):1409-1420.
doi: 10.1007/s00394-016-1187-z. Epub 2016 Feb 25.

Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study

Giuseppe Grosso  1   2 , Urszula Stepaniak  3 , Agnieszka Micek  3 , Denes Stefler  4 , Martin Bobak  4 , Andrzej Pająk  3
Affiliations

Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study

Giuseppe Grosso et al. Eur J Nutr. 2017 Jun.

Abstract

Purpose: The aim of this study was to evaluate the association between total and individual classes and subclasses of dietary polyphenol intake and prevalence of metabolic syndrome (MetS) in the Polish arm of the Health, Alcohol and Psychosocial factors In Eastern Europe cohort study.

Methods: A cross-sectional population-based survey including 8821 adults (51.4 % female) was conducted in Kraków, Poland. Dietary polyphenol intake was evaluated using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database. MetS was defined according to the International Diabetes Federation definition. Linear and logistic regression models were performed to estimate odds ratios (ORs) and confidence intervals (CIs).

Results: Significant differences in age and energy intake among different categories of total dietary polyphenol intake were found. Body mass index (BMI), waist circumference (WC), blood pressure, and triglycerides were significantly lower among individuals in the higher quartiles of polyphenol intake, but a linear association was found only for BMI and WC. After adjusting for potential confounding factors, individuals in the highest quartile of polyphenol intake were less likely to have MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively). High total polyphenol intake was negatively associated with WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both genders. Among individual classes of polyphenols, phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose. Among specific subclasses of polyphenols, hydroxycinnamic acids, flavanols, and dihydrochalcones had the most relevant role.

Conclusions: Total and individual classes and subclasses of dietary polyphenols were inversely associated with MetS and some of its components.

Keywords: Blood pressure; Dietary polyphenols; Dyslipidemia; Flavonoids; Hyperglycemia; Lignans; Metabolic syndrome; Phenolic acids; Stilbenes; Waist circumference.

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Conflict of interest statement

Authors declare that they have no conflict of interest.

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References

    1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Jr, Spertus JA, Costa F, American Heart A, National Heart L, Blood I. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752. doi: 10.1161/CIRCULATIONAHA.105.169404. - DOI - PubMed
    1. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch-Johnsen K, Pyorala K. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med. 2004;164:1066–1076. doi: 10.1001/archinte.164.10.1066. - DOI - PubMed
    1. Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35:2402–2411. doi: 10.2337/dc12-0336. - DOI - PMC - PubMed
    1. Buscemi S, Sprini D, Grosso G, Galvano F, Nicolucci A, Lucisano G, Massenti FM, Amodio E, Rini GB. Impact of lifestyle on metabolic syndrome in apparently healthy people. Eat Weight Disord. 2014;19:225–232. doi: 10.1007/s40519-014-0117-4. - DOI - PubMed
    1. Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E, Arrigo T. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014;16:378–400. doi: 10.3390/ijms16010378. - DOI - PMC - PubMed

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