Innovative hybrid vs polymeric nanocapsules: The influence of the cationic lipid coating on the "4S"
- PMID: 26895507
- DOI: 10.1016/j.colsurfb.2016.02.002
Innovative hybrid vs polymeric nanocapsules: The influence of the cationic lipid coating on the "4S"
Abstract
Polymeric and hybrid aqueous-core nanocapsules were prepared using a low energy organic-solvent free procedure as innovative nanodevices for the ophthalmic delivery of melatonin. In order to evaluate how different cationic lipids could affect the main properties of the nanodevices, we focused our attention on mean particles size, surface charge, shape and stability (the "4S"). The results of our study confirmed the hypothesis that the coating material differently affects the overall nanoparticles properties, above all in terms of morphology: in particular, the cationic lipid dimethyldioctadecylammonium bromide allows the formation of very stable well-defined nanocapsules with non-spherical shape with sustained and prolonged drug release, thus representing a great advantage in ophthalmic application.
Keywords: CTAB; DDAB; Ocular; PLA; Shape; Size; Stability; Surface charge; Sustained release.
Copyright © 2016 Elsevier B.V. All rights reserved.
Similar articles
-
Eco-friendly aqueous core surface-modified nanocapsules.Colloids Surf B Biointerfaces. 2015 Jan 1;125:190-6. doi: 10.1016/j.colsurfb.2014.11.038. Epub 2014 Dec 2. Colloids Surf B Biointerfaces. 2015. PMID: 25497291
-
Incorporation in polymeric nanocapsules improves the antioxidant effect of melatonin against lipid peroxidation in mice brain and liver.Eur J Pharm Biopharm. 2008 May;69(1):64-71. doi: 10.1016/j.ejpb.2007.11.010. Epub 2007 Nov 23. Eur J Pharm Biopharm. 2008. PMID: 18182281
-
Nanocapsules, nanoemulsion and nanodispersion containing melatonin: preparation, characterization and stability evaluation.Pharmazie. 2007 May;62(5):354-60. Pharmazie. 2007. PMID: 17557743
-
Applications of polymeric nanocapsules in field of drug delivery systems.Curr Drug Discov Technol. 2011 Sep;8(3):173-87. doi: 10.2174/157016311796799008. Curr Drug Discov Technol. 2011. PMID: 21644922 Review.
-
Lipid Nanocapsule: A Novel Approach to Drug Delivery System Formulation Development.Curr Pharm Biotechnol. 2024;25(3):268-284. doi: 10.2174/1389201024666230523114350. Curr Pharm Biotechnol. 2024. PMID: 37231750 Review.
Cited by
-
The Therapeutic Trip of Melatonin Eye Drops: From the Ocular Surface to the Retina.Pharmaceuticals (Basel). 2024 Mar 29;17(4):441. doi: 10.3390/ph17040441. Pharmaceuticals (Basel). 2024. PMID: 38675402 Free PMC article. Review.
-
A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders-A Systematic Review.Int J Mol Sci. 2024 Apr 3;25(7):3999. doi: 10.3390/ijms25073999. Int J Mol Sci. 2024. PMID: 38612812 Free PMC article. Review.
-
Formulation and Characterization of Electrospun Nanofibers for Melatonin Ocular Delivery.Pharmaceutics. 2023 Apr 20;15(4):1296. doi: 10.3390/pharmaceutics15041296. Pharmaceutics. 2023. PMID: 37111782 Free PMC article.
-
Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer's Disease.Biomedicines. 2022 Apr 23;10(5):985. doi: 10.3390/biomedicines10050985. Biomedicines. 2022. PMID: 35625722 Free PMC article.
-
Therapeutic Effects of Melatonin on Ocular Diseases: Knowledge Map and Perspective.Front Pharmacol. 2021 Nov 2;12:721869. doi: 10.3389/fphar.2021.721869. eCollection 2021. Front Pharmacol. 2021. PMID: 34795578 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
