Maternal immunization with respiratory syncytial virus fusion protein formulated with a novel combination adjuvant provides protection from RSV in newborn lambs
- PMID: 26616551
- DOI: 10.1016/j.vaccine.2015.11.029
Maternal immunization with respiratory syncytial virus fusion protein formulated with a novel combination adjuvant provides protection from RSV in newborn lambs
Abstract
Respiratory syncytial virus (RSV) is the causative agent of serious upper and lower respiratory tract infections in newborns and infants. Protection from RSV is crucial for neonates, and maternal immunization is one approach that holds promise for providing immediate protection to young infants against severe RSV infection. We previously reported efficacy of a subunit vaccine consisting of the fusion (F) protein formulated with a novel adjuvant (ΔF/TriAdj) in neonates. The goal of the current study was to evaluate the ΔF/TriAdj as a maternal vaccine. Pregnant ewes were vaccinated intramuscularly with ΔF/TriAdj or PBS six weeks prior to lambing, and re-vaccinated four weeks later, which resulted in transfer of maternal antibodies (MatAbs) to the newborn lambs through the colostrum. Significantly higher levels of RSV ΔF-specific serum IgG were detected in vaccinated pregnant ewes and their lambs when compared to control animals, which revealed that MatAbs were passively transferred to the offspring. All newborn lambs were challenged with RSV at three days of age. After RSV challenge, virus production and lung pathology were significantly lower in lambs that had received passively transferred antibodies than in control animals. These results indicate that maternal immunization with ΔF/TriAdj might be an alternative, safe and effective approach to provide protection against RSV in newborn and young infants.
Keywords: Animal model; Maternal antibodies; Maternal immunization; Newborn lambs; Protection; RSV.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Similar articles
-
The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies.Vaccine. 2015 Mar 10;33(11):1338-44. doi: 10.1016/j.vaccine.2015.01.041. Epub 2015 Jan 28. Vaccine. 2015. PMID: 25637860
-
Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs.Antiviral Res. 2019 Feb;162:54-60. doi: 10.1016/j.antiviral.2018.12.010. Epub 2018 Dec 12. Antiviral Res. 2019. PMID: 30550799
-
Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity.J Gen Virol. 2014 May;95(Pt 5):1043-1054. doi: 10.1099/vir.0.062570-0. Epub 2014 Feb 26. J Gen Virol. 2014. PMID: 24572813
-
Respiratory syncytial virus in infants: is maternal vaccination a realistic strategy?Curr Opin Infect Dis. 2015 Jun;28(3):221-4. doi: 10.1097/QCO.0000000000000161. Curr Opin Infect Dis. 2015. PMID: 25918956 Review.
-
Immunopathology of RSV infection: prospects for developing vaccines without this complication.Rev Med Virol. 2007 Jan-Feb;17(1):5-34. doi: 10.1002/rmv.518. Rev Med Virol. 2007. PMID: 17004293 Review.
Cited by
-
Establishment and application of a lethal model of an HRSV-long variant strain in BALB/c mice.Exp Anim. 2022 Nov 10;71(4):500-509. doi: 10.1538/expanim.22-0042. Epub 2022 Jun 23. Exp Anim. 2022. PMID: 35732419 Free PMC article.
-
HRSV prefusion-F protein with Adju-Phos adjuvant induces long-lasting Th2-biased immunity in mice.PLoS One. 2022 Jan 31;17(1):e0262231. doi: 10.1371/journal.pone.0262231. eCollection 2022. PLoS One. 2022. PMID: 35100303 Free PMC article.
-
Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats.PLoS Pathog. 2021 Dec 23;17(12):e1009856. doi: 10.1371/journal.ppat.1009856. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34941963 Free PMC article.
-
Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs.Pathogens. 2021 Nov 5;10(11):1441. doi: 10.3390/pathogens10111441. Pathogens. 2021. PMID: 34832599 Free PMC article.
-
Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection.Sci Rep. 2021 Sep 20;11(1):18641. doi: 10.1038/s41598-021-97535-6. Sci Rep. 2021. PMID: 34545126 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical