Amniotic fluid prostaglandin E2 in pregnancies complicated by preterm prelabor rupture of the membranes
- PMID: 26512976
- DOI: 10.3109/14767058.2015.1112372
Amniotic fluid prostaglandin E2 in pregnancies complicated by preterm prelabor rupture of the membranes
Abstract
Objective: To determine amniotic fluid prostaglandin E2 concentrations in women preterm prelabor rupture of the membranes (PPROM) with respect to microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI), microbial-associated IAI, histological chorioamnionitis, and short-term neonatal morbidity.
Methods: One hundred forty-five women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for prostaglandin E2 concentrations by ELISA. IAI was defined as amniotic fluid interleukin-6 >745 pg/mL. Microbial-associated IAI was defined as the presence of both MIAC and IAI.
Result: No differences in prostaglandin E2 concentrations were found between women with and without MIAC (p = 0.27). Women with IAI (p = 0.0008) and microbial-associated IAI (p = 0.01) had higher prostaglandin E2 concentrations than women without these complications. Women with histological chorioamnionitis had higher prostaglandin E2 concentrations only in crude analysis (p = 0.02), but not after adjustment for gestational age at sampling (p = 0.10). No associations between amniotic fluid prostaglandin E2 concentrations and the selected conditions of severe neonatal morbidity were found.
Conclusions: The intraamniotic inflammatory response either to infectious or to non-infectious stimulus, but not MIAC per se, seems to be a main factor associated with the elevation of the amniotic fluid PGE2 concentrations in women with PPROM.
Keywords: Infection; inflammation; placenta; preterm delivery.
Similar articles
-
[Current approach in preterm prelabor rupture of membranes: new definitions? Is CRP determination useful? Are alternatives in sight?].Gynakologe. 2021;54(3):186-194. doi: 10.1007/s00129-021-04750-3. Epub 2021 Feb 16. Gynakologe. 2021. PMID: 33612852 Free PMC article. Review. German.
-
Cervical fluid interleukin 6 and intra-amniotic complications of preterm prelabor rupture of membranes.J Matern Fetal Neonatal Med. 2018 Apr;31(7):827-836. doi: 10.1080/14767058.2017.1297792. Epub 2017 Mar 9. J Matern Fetal Neonatal Med. 2018. PMID: 28277919
-
Amniotic fluid cathepsin-G in pregnancies complicated by the preterm prelabor rupture of membranes.J Matern Fetal Neonatal Med. 2017 Sep;30(17):2097-2104. doi: 10.1080/14767058.2016.1237499. Epub 2016 Oct 9. J Matern Fetal Neonatal Med. 2017. PMID: 27651029
-
Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes.J Matern Fetal Neonatal Med. 2016 Dec;29(24):3921-9. doi: 10.3109/14767058.2016.1154940. Epub 2016 Mar 8. J Matern Fetal Neonatal Med. 2016. PMID: 26953684
-
[Management of preterm prelabor rupture of membranes with respect to the inflammatory complications - our experiences].Ceska Gynekol. 2013 Dec;78(6):509-13. Ceska Gynekol. 2013. PMID: 24372427 Review. Czech.
Cited by
-
The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review.Front Endocrinol (Lausanne). 2021 Sep 6;12:668417. doi: 10.3389/fendo.2021.668417. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34552554 Free PMC article.
-
[Clinical features of very preterm infants with prelabor rupture of membranes and predictive factors for major adverse outcomes].Zhongguo Dang Dai Er Ke Za Zhi. 2021 Jun;23(6):575-581. doi: 10.7499/j.issn.1008-8830.2012177. Zhongguo Dang Dai Er Ke Za Zhi. 2021. PMID: 34130778 Free PMC article. Chinese.
-
Preterm labor is characterized by a high abundance of amniotic fluid prostaglandins in patients with intra-amniotic infection or sterile intra-amniotic inflammation.J Matern Fetal Neonatal Med. 2021 Dec;34(24):4009-4024. doi: 10.1080/14767058.2019.1702953. Epub 2019 Dec 29. J Matern Fetal Neonatal Med. 2021. PMID: 31885290 Free PMC article.
-
Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency.Am J Obstet Gynecol. 2019 Aug;221(2):140.e1-140.e18. doi: 10.1016/j.ajog.2019.03.017. Epub 2019 Mar 28. Am J Obstet Gynecol. 2019. PMID: 30928565 Free PMC article.
-
Maternal white blood cell count cannot identify the presence of microbial invasion of the amniotic cavity or intra-amniotic inflammation in women with preterm prelabor rupture of membranes.PLoS One. 2017 Dec 12;12(12):e0189394. doi: 10.1371/journal.pone.0189394. eCollection 2017. PLoS One. 2017. PMID: 29232399 Free PMC article.
MeSH terms
Substances
Supplementary concepts
LinkOut - more resources
Full Text Sources