Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
- PMID: 26457551
- PMCID: PMC5008686
- DOI: 10.1038/nn.4135
Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
Abstract
Functional magnetic resonance imaging (fMRI) studies typically collapse data from many subjects, but brain functional organization varies between individuals. Here we establish that this individual variability is both robust and reliable, using data from the Human Connectome Project to demonstrate that functional connectivity profiles act as a 'fingerprint' that can accurately identify subjects from a large group. Identification was successful across scan sessions and even between task and rest conditions, indicating that an individual's connectivity profile is intrinsic, and can be used to distinguish that individual regardless of how the brain is engaged during imaging. Characteristic connectivity patterns were distributed throughout the brain, but the frontoparietal network emerged as most distinctive. Furthermore, we show that connectivity profiles predict levels of fluid intelligence: the same networks that were most discriminating of individuals were also most predictive of cognitive behavior. Results indicate the potential to draw inferences about single subjects on the basis of functional connectivity fMRI.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5008686/bin/nihms723561f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5008686/bin/nihms723561f2.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5008686/bin/nihms723561f3.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5008686/bin/nihms723561f4.gif)
![Figure 5](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5008686/bin/nihms723561f5.gif)
Comment in
-
fMRI goes individual.Nat Methods. 2015 Dec;12(12):1112-3. doi: 10.1038/nmeth.3677. Nat Methods. 2015. PMID: 26962579 No abstract available.
-
Fingerprinting by fMRI: from populations to individual patterns of functional connectivity.Neuroscientist. 2016 Apr;22(2):105. doi: 10.1177/1073858416630735. Neuroscientist. 2016. PMID: 26985071 No abstract available.
-
Commentary: Functional connectome fingerprint: identifying individuals using patterns of brain connectivity.Front Hum Neurosci. 2017 Feb 7;11:47. doi: 10.3389/fnhum.2017.00047. eCollection 2017. Front Hum Neurosci. 2017. PMID: 28223928 Free PMC article. No abstract available.
-
How could brain fingerprinting lead to the early detection of mental illness in adolescents and what are the next steps?Expert Rev Neurother. 2023 Jul-Dec;23(7):567-570. doi: 10.1080/14737175.2023.2226870. Epub 2023 Jun 19. Expert Rev Neurother. 2023. PMID: 37323019 No abstract available.
Similar articles
-
Functional Connectome from Phase Synchrony at Resting State is a Neural Fingerprint.Brain Connect. 2019 Sep;9(7):519-528. doi: 10.1089/brain.2018.0657. Epub 2019 Jun 28. Brain Connect. 2019. PMID: 30997813
-
Identifying inter-individual differences in pain threshold using brain connectome: a test-retest reproducible study.Neuroimage. 2019 Nov 15;202:116049. doi: 10.1016/j.neuroimage.2019.116049. Epub 2019 Jul 23. Neuroimage. 2019. PMID: 31349067 Free PMC article.
-
Brain fingerprinting and cognitive behavior predicting using functional connectome of high inter-subject variability.Neuroimage. 2024 Jul 15;295:120651. doi: 10.1016/j.neuroimage.2024.120651. Epub 2024 May 23. Neuroimage. 2024. PMID: 38788914
-
Can brain state be manipulated to emphasize individual differences in functional connectivity?Neuroimage. 2017 Oct 15;160:140-151. doi: 10.1016/j.neuroimage.2017.03.064. Epub 2017 Mar 31. Neuroimage. 2017. PMID: 28373122 Free PMC article. Review.
-
The Prediction of Brain Activity from Connectivity: Advances and Applications.Neuroscientist. 2024 Jun;30(3):367-377. doi: 10.1177/10738584221130974. Epub 2022 Oct 17. Neuroscientist. 2024. PMID: 36250457 Free PMC article. Review.
Cited by
-
The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology. 2024 Jul 31. doi: 10.1038/s41386-024-01941-z. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 39085426 Review.
-
Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population.Mol Psychiatry. 2024 Jul 31. doi: 10.1038/s41380-024-02683-6. Online ahead of print. Mol Psychiatry. 2024. PMID: 39085394
-
LOCUS: A REGULARIZED BLIND SOURCE SEPARATION METHOD WITH LOW-RANK STRUCTURE FOR INVESTIGATING BRAIN CONNECTIVITY.Ann Appl Stat. 2023 Jun;17(2):1307-1332. doi: 10.1214/22-aoas1670. Epub 2023 May 1. Ann Appl Stat. 2023. PMID: 39040949 Free PMC article.
-
Evaluation of Brain Function Recovery After Traumatic Brain Injury Treatment in a Porcine Model by Cross-Group Temporal-Spatial Correlation Analysis.Neurotrauma Rep. 2024 Jul 1;5(1):617-627. doi: 10.1089/neur.2023.0059. eCollection 2024. Neurotrauma Rep. 2024. PMID: 39036426
-
Connectome predictive modeling of trait mindfulness.bioRxiv [Preprint]. 2024 Jul 14:2024.07.09.602725. doi: 10.1101/2024.07.09.602725. bioRxiv. 2024. PMID: 39026870 Free PMC article. Preprint.
References
-
- Mangin JF, Rivière D, Cachia A, Duchesnay E, Cointepas Y, et al. A framework to study the cortical folding patterns. Neuroimage. 2004;23(Suppl 1):S129–S138. - PubMed
-
- Amunts K, Malikovic A, Mohlberg H, Schormann T, Zilles K. Brodmann's areas 17 and 18 brought into stereotaxic space-where and how variable? Neuroimage. 2000;11:66–84. - PubMed
-
- Bürgel U, Amunts K, Hoemke L, Mohlberg H, Gilsbach JM, et al. White matter fiber tracts of the human brain: three-dimensional mapping at microscopic resolution, topography and intersubject variability. Neuroimage. 2006;29:1092–1105. - PubMed
-
- Grabner RH, Ansari D, Reishofer G, Stern E, Ebner F, et al. Individual differences in mathematical competence predict parietal brain activation during mental calculation. Neuroimage. 2007;38:346–356. - PubMed
-
- Newman SD, Carpenter PA, Varma S, Just MA. Frontal and parietal participation in problem solving in the Tower of London: fMRI and computational modeling of planning and high-level perception. Neuropsychologia. 2003;41:1668–1682. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources