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Multicenter Study
. 2015 Nov:70:91-7.
doi: 10.1016/j.jpsychires.2015.09.001. Epub 2015 Sep 3.

The pro-inflammatory profile of depressed patients is (partly) related to obesity

Richard C Shelton  1 , Michael Falola  2 , Li Li  2 , John Zajecka  3 , Maurizio Fava  4 , George I Papakostas  4
Affiliations
Multicenter Study

The pro-inflammatory profile of depressed patients is (partly) related to obesity

Richard C Shelton et al. J Psychiatr Res. 2015 Nov.

Abstract

Many people with major depressive disorder (MDD) show evidence of systemic inflammation, including elevations in inflammatory factors, but the cause is unclear. The purpose of this analysis was to determine if obesity might contribute to the pro-inflammatory state in MDD patients. Blood was obtained from 135 MDD patients and 50 controls. Serum was extracted and assayed for interleukin (IL) -1β, IL-2, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, interferon-γ (IFNγ), tumor necrosis factor α (TNFα), C-reactive protein (CRP), leptin, and adiponectin using single- or multi-plex human immunoassay kits. The primary analysis contrasted IL-6, TNFα, and CRP between MDD and control groups with body mass index (BMI) as a covariate. The other analytes were compared in an exploratory fashion. IL-6 (but not TNFα or CRP) showed significant differences between MDD and controls even after covarying for BMI. Obese controls and obese MDD groups were significantly higher in IL-6 than both lean groups, but the two obese groups did not differ from each other. In the exploratory analyses, the IL-2 level showed robust and significant differences between MDD and controls even after covarying for BMI. Both lean and obese MDD were higher than lean and obese controls. Adiponectin levels were also lower in the MDD sample than controls. Prior findings of higher IL-6, and CRP in MDD patients may be explained, at least in part, based on obesity. High IL-2, however, was associated with depression and not obesity. The results have significant implications for the understanding of pathophysiology and, potentially treatment of MDD.

Keywords: Adiponectin; C-reactive protein; Cytokine; Depression; Inflammation; Leptin.

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* p=0.05 versus non-obese controls ** fp<0.001 versus non-obese controls and non-obese depressed
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References

    1. Akbaraly TN, Kivimaki M, Brunner EJ, Chandola T, Marmot MG, Singh-Manoux A, et al. Association between metabolic syndrome and depressive symptoms in middle-aged adults: results from the Whitehall II study. Diabetes Care. 2009;32:499–504. - PMC - PubMed
    1. Almeida OP, Calver J, Jamrozik K, Hankey GJ, Flicker L. Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men study. Am J GeriatrPsychiatry. 2009;17:889–898. - PubMed
    1. Basterzi AD, Aydemir C, Kisa C, Aksaray S, Tuzer V, Yazici K, et al. IL-6 levels decrease with SSRI treatment in patients with major depression. HumPsychopharmacol. 2005;20:473–476. - PubMed
    1. Benson S, Janssen OE, Hahn S, Tan S, Dietz T, Mann K, et al. Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome. Brain BehavImmun. 2008;22:177–184. - PubMed
    1. Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:1920–1925. - PMC - PubMed

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