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Review
. 2015 Nov;64(11):1395-407.
doi: 10.1016/j.metabol.2015.08.006. Epub 2015 Aug 15.

Weight regaining: From statistics and behaviors to physiology and metabolism

Costas A Anastasiou  1 , Eleni Karfopoulou  2 , Mary Yannakoulia  2
Affiliations
Review

Weight regaining: From statistics and behaviors to physiology and metabolism

Costas A Anastasiou et al. Metabolism. 2015 Nov.

Abstract

Achieving maintenance of weight loss is crucial to combat obesity. However, most individuals tend to regain weight. Data from successful maintainers show that they remain vigilant and constantly apply techniques to oppose the course of regaining. On the other hand, current advances in obesity research show that the reduced obese state is a state of altered physiology in terms of energy balance. This review describes the physiological adaptations occurring after weight loss that predispose to regaining. Specifically, changes regarding body composition, hormonal background, energy expenditure and control of food intake are discussed. Moreover, metabolites that can act as regain predictors and dietary techniques to oppose regaining are presented.

Keywords: Weight loss adaptations; Weight loss maintenance; Weight regain; Weight regain predictors.

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