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Review
. 2016 Jan:100:27-39.
doi: 10.1016/j.neuropharm.2015.06.019. Epub 2015 Aug 12.

IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders

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Free article
Review

IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders

Jaeseung Kang et al. Neuropharmacology. 2016 Jan.
Free article

Abstract

IRSp53 (also known as BAIAP2) is a multi-domain scaffolding and adaptor protein that has been implicated in the regulation of membrane and actin dynamics at subcellular structures, including filopodia and lamellipodia. Accumulating evidence indicates that IRSp53 is an abundant component of the postsynaptic density at excitatory synapses and an important regulator of actin-rich dendritic spines. In addition, IRSp53 has been implicated in diverse psychiatric disorders, including autism spectrum disorders, schizophrenia, and attention deficit/hyperactivity disorder. Mice lacking IRSp53 display enhanced NMDA (N-methyl-d-aspartate) receptor function accompanied by social and cognitive deficits, which are reversed by pharmacological suppression of NMDA receptor function. These results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through NMDA receptor dysfunction. This article is part of the Special Issue entitled 'Synaptopathy--from Biology to Therapy'.

Keywords: Actin; Dendritic spine; IRSp53; Membrane; NMDA receptor; Psychiatric disorders.

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