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Clinical Trial
. 2015:2015:386326.
doi: 10.1155/2015/386326. Epub 2015 Jun 9.

The Altered Triple Networks Interaction in Depression under Resting State Based on Graph Theory

Hongna Zheng  1 , Lele Xu  1 , Fufang Xie  1 , Xiaojuan Guo  1 , Jiacai Zhang  1 , Li Yao  2 , Xia Wu  3
Affiliations
Clinical Trial

The Altered Triple Networks Interaction in Depression under Resting State Based on Graph Theory

Hongna Zheng et al. Biomed Res Int. 2015.

Abstract

The triple network model (Menon, 2011) has been proposed, which helps with finding a common framework for understanding the dysfunction in core neurocognitive network across multiple disorders. The alteration of the triple networks in the major depression disorder (MDD) is not clear. In our study, the altered interaction of the triple networks, which include default model network (DMN), central executive network (CEN), and salience network (SN), was examined in the MDD by graph theory method. The results showed that the connectivity degree of right anterior insula (rAI) significantly increased in MDD compared with healthy control (HC), and the connectivity degree between DMN and CEN significantly decreased in MDD. These results not only supported the proposal of the triple network model, but also prompted us to understand the dysfunction of neural mechanism in MDD.

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Figures

Figure 1
Figure 1
The DMN, CEN, and SN spatial pattern maps of HC and MDD. The statistical maps displaying one sample t-test of the two groups, with the color scale representing the ranges of t-values.
Figure 2
Figure 2
The region connectivity degree of MDD and HC. In (a) the size of the node visualizes the value of the connectivity degree Γ- of all the 11 nodes. Red dot indicates the nodes that significantly altered for the MDD compared to HC; the other colored dots mean “not significant.” The blue dots are the nodes in DMN and dark green dots in CEN; bright green dots indicate the nodes in SN. (b) shows the Γ- of all the 11 nodes (∗ represents significance with P < 0.05).
Figure 3
Figure 3
The interregional connection η between rAI and other brain regions in MDD and HC. (a) The lines showed the visualization of η. (b) shows the value η between the rAI and all the other nodes.
Figure 4
Figure 4
The connectivity degree Γ between the networks. Γ is the functional connectivity degree between the networks for the two groups (∗ represents significance by two-sample t-test).
See this image and copyright information in PMC

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