Epigenetics in acute kidney injury
- PMID: 26050122
- PMCID: PMC4559861
- DOI: 10.1097/MNH.0000000000000140
Epigenetics in acute kidney injury
Abstract
Purpose of review: Recent advances in epigenetics indicate the involvement of several epigenetic modifications in the pathogenesis of acute kidney injury (AKI). The purpose of this review is to summarize our understanding of recent advances in the epigenetic regulation of AKI and provide mechanistic insight into the role of acetylation, methylation, and microRNA expression in the pathological processes of AKI.
Recent findings: Enhancement of protein acetylation by pharmacological inhibition of histone deacetylases leads to more severe tubular injury and impairment of renal structural and functional recovery. The changes in promoter DNA methylation occur in the kidney with ischemia/reperfusion. microRNA expression is associated with regulation of both renal injury and regeneration after AKI.
Summary: Recent studies on epigenetic regulation indicate that acetylation, methylation, and microRNA expression are critically implicated in the pathogenesis of AKI. Strategies targeting epigenetic processes may hold a therapeutic potential for patients with AKI.
Conflict of interest statement
No conflicts of interest
Similar articles
-
Epigenetic targeting for acute kidney injury.Nephrology (Carlton). 2018 Oct;23 Suppl 4:21-25. doi: 10.1111/nep.13466. Nephrology (Carlton). 2018. PMID: 30298650 Review.
-
Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications.Nat Rev Nephrol. 2019 Apr;15(4):220-239. doi: 10.1038/s41581-018-0103-6. Nat Rev Nephrol. 2019. PMID: 30651611 Free PMC article. Review.
-
Targeting epigenetic DNA and histone modifications to treat kidney disease.Nephrol Dial Transplant. 2018 Nov 1;33(11):1875-1886. doi: 10.1093/ndt/gfy009. Nephrol Dial Transplant. 2018. PMID: 29534238 Review.
-
Histone acetylation and DNA methylation in ischemia/reperfusion injury.Clin Sci (Lond). 2019 Feb 25;133(4):597-609. doi: 10.1042/CS20180465. Print 2019 Feb 28. Clin Sci (Lond). 2019. PMID: 30804072 Free PMC article. Review.
-
Epigenetic regulation in acute kidney injury: new light in a dark area.Kidney Int. 2015 Oct;88(4):665-8. doi: 10.1038/ki.2015.229. Kidney Int. 2015. PMID: 26422622 Free PMC article.
Cited by
-
The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury.Int J Mol Sci. 2023 May 4;24(9):8254. doi: 10.3390/ijms24098254. Int J Mol Sci. 2023. PMID: 37175958 Free PMC article. Review.
-
Acute kidney disease: an overview of the epidemiology, pathophysiology, and management.Kidney Res Clin Pract. 2023 Nov;42(6):686-699. doi: 10.23876/j.krcp.23.001. Epub 2023 May 11. Kidney Res Clin Pract. 2023. PMID: 37165615 Free PMC article.
-
Protein arginine methyltransferases in renal development, injury, repair, and fibrosis.Front Pharmacol. 2023 Feb 3;14:1123415. doi: 10.3389/fphar.2023.1123415. eCollection 2023. Front Pharmacol. 2023. PMID: 36817133 Free PMC article. Review.
-
Histone Modifications in Acute Kidney Injury.Kidney Dis (Basel). 2022 Nov 10;8(6):466-477. doi: 10.1159/000527799. eCollection 2022 Dec. Kidney Dis (Basel). 2022. PMID: 36590679 Free PMC article. Review.
-
Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.Int J Mol Sci. 2022 Aug 24;23(17):9582. doi: 10.3390/ijms23179582. Int J Mol Sci. 2022. PMID: 36076983 Free PMC article.
References
-
- Rewa O, Bagshaw SM. Acute kidney injury-epidemiology, outcomes and economics. Nat Rev Nephrol. 2014;10:193–207. - PubMed
-
- Kelly KJ. Acute renal failure: Much more than a kidney disease. Semin Nephrol. 2006;26:105–113. - PubMed
-
- Wen X, Murugan R, Peng Z, et al. Pathophysiology of acute kidney injury: A new perspective. Contrib Nephrol. 2010;165:39–45. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials