Natriuretic peptide control of energy balance and glucose homeostasis
- PMID: 26037452
- DOI: 10.1016/j.biochi.2015.05.017
Natriuretic peptide control of energy balance and glucose homeostasis
Abstract
Cardiac natriuretic peptides (NP) have recently emerged as metabolic hormones. Physiological stimulation of cardiac NP release as during exercise may contribute to increase fatty acid mobilization from adipose tissue and their oxidation by skeletal muscles. Clinical studies have shown that although very high plasma NP level characterizes cardiac dysfunction and heart failure, a consistently reduced plasma NP level is observed in metabolic diseases such as obesity and type 2 diabetes. A low circulating NP level also predicts the risk of new onset type 2 diabetes. It is unclear at this stage if the "natriuretic handicap" observed in obesity is causally associated with the incidence of type 2 diabetes. Recent work indicates that NP can activate a thermogenic program in brown and white fat, increase energy expenditure and inhibit food intake. Mouse studies also argue for a key role of NP in the regulation of energy balance and glucose homeostasis. This review will focus on recent human and mouse studies to highlight the metabolic roles of NP and their potential relevance in the context of obesity and type 2 diabetes.
Keywords: Lipid metabolism; Natriuretic peptides; Obesity; Skeletal muscle; Type 2 diabetes; cGMP.
Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
Similar articles
-
Divergent effects of a designer natriuretic peptide CD-NP in the regulation of adipose tissue and metabolism.Mol Metab. 2017 Jan 4;6(3):276-287. doi: 10.1016/j.molmet.2016.12.010. eCollection 2017 Mar. Mol Metab. 2017. PMID: 28271034 Free PMC article.
-
Natriuretic peptides and fat metabolism.Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):645-9. doi: 10.1097/MCO.0b013e32836510ed. Curr Opin Clin Nutr Metab Care. 2013. PMID: 23945222 Review.
-
Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism.Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E691-714. doi: 10.1152/ajpendo.00297.2015. Epub 2015 Sep 1. Am J Physiol Endocrinol Metab. 2015. PMID: 26330344 Review.
-
[The secretory function of skeletal muscles and its role in energy metabolism and utilization].Orv Hetil. 2014 Sep 14;155(37):1469-77. doi: 10.1556/OH.2014.29959. Orv Hetil. 2014. PMID: 25194869 Review. Hungarian.
-
Fibroblast growth factor-21, energy balance and obesity.Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:66-73. doi: 10.1016/j.mce.2015.09.018. Epub 2015 Sep 26. Mol Cell Endocrinol. 2015. PMID: 26415590 Review.
Cited by
-
Cardiac-to-adipose axis in metabolic homeostasis and diseases: special instructions from the heart.Cell Biosci. 2023 Sep 4;13(1):161. doi: 10.1186/s13578-023-01097-1. Cell Biosci. 2023. PMID: 37667400 Free PMC article. Review.
-
The cardio-renal-metabolic connection: a review of the evidence.Cardiovasc Diabetol. 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. Cardiovasc Diabetol. 2023. PMID: 37525273 Free PMC article. Review.
-
Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function.Biomedicines. 2023 Jun 23;11(7):1794. doi: 10.3390/biomedicines11071794. Biomedicines. 2023. PMID: 37509434 Free PMC article. Review.
-
Pathophysiology of obesity and its associated diseases.Acta Pharm Sin B. 2023 Jun;13(6):2403-2424. doi: 10.1016/j.apsb.2023.01.012. Epub 2023 Jan 13. Acta Pharm Sin B. 2023. PMID: 37425065 Free PMC article. Review.
-
Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena.J Diabetes. 2023 May;15(5):397-408. doi: 10.1111/1753-0407.13389. Epub 2023 Apr 19. J Diabetes. 2023. PMID: 37078106 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous