The brain's default mode network
- PMID: 25938726
- DOI: 10.1146/annurev-neuro-071013-014030
The brain's default mode network
Abstract
The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its discovery was an unexpected consequence of brain-imaging studies first performed with positron emission tomography in which various novel, attention-demanding, and non-self-referential tasks were compared with quiet repose either with eyes closed or with simple visual fixation. The default mode network consistently decreases its activity when compared with activity during these relaxed nontask states. The discovery of the default mode network reignited a longstanding interest in the significance of the brain's ongoing or intrinsic activity. Presently, studies of the brain's intrinsic activity, popularly referred to as resting-state studies, have come to play a major role in studies of the human brain in health and disease. The brain's default mode network plays a central role in this work.
Keywords: activation; attention; baseline; functional connectivity; intrinsic activity; memory; resting state; self.
Similar articles
-
Mapping the self in the brain's default mode network.Neuroimage. 2016 May 15;132:390-397. doi: 10.1016/j.neuroimage.2016.02.022. Epub 2016 Feb 15. Neuroimage. 2016. PMID: 26892855
-
A dual-subsystem model of the brain's default network: self-referential processing, memory retrieval processes, and autobiographical memory retrieval.Neuroimage. 2012 Jul 16;61(4):966-77. doi: 10.1016/j.neuroimage.2012.03.025. Epub 2012 Mar 15. Neuroimage. 2012. PMID: 22446489
-
Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation.J Cogn Neurosci. 2004 Nov;16(9):1484-92. doi: 10.1162/0898929042568532. J Cogn Neurosci. 2004. PMID: 15601513 Clinical Trial.
-
Rest-stimulus interaction in the brain: a review.Trends Neurosci. 2010 Jun;33(6):277-84. doi: 10.1016/j.tins.2010.02.006. Epub 2010 Mar 11. Trends Neurosci. 2010. PMID: 20226543 Review.
-
The brain and its resting state activity--experimental and methodological implications.Prog Neurobiol. 2010 Dec;92(4):593-600. doi: 10.1016/j.pneurobio.2010.09.002. Epub 2010 Oct 1. Prog Neurobiol. 2010. PMID: 20888388 Review.
Cited by
-
Macroscale brain states support the control of semantic cognition.Commun Biol. 2024 Aug 1;7(1):926. doi: 10.1038/s42003-024-06630-7. Commun Biol. 2024. PMID: 39090387
-
Explaining recovery from coma with multimodal neuroimaging.J Neurol. 2024 Aug 1. doi: 10.1007/s00415-024-12591-y. Online ahead of print. J Neurol. 2024. PMID: 39090230
-
The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology. 2024 Jul 31. doi: 10.1038/s41386-024-01941-z. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 39085426 Review.
-
Heightened emotion processing as a compensatory mechanism in persons with Alzheimer's disease: Psychological insights from the tri-network model.Front Dement. 2022 Sep 30;1:983331. doi: 10.3389/frdem.2022.983331. eCollection 2022. Front Dement. 2022. PMID: 39081476 Free PMC article. Review.
-
A mediation approach in resting-state connectivity between the medial prefrontal cortex and anterior cingulate in mild cognitive impairment.Aging Clin Exp Res. 2024 Jul 30;36(1):154. doi: 10.1007/s40520-024-02805-8. Aging Clin Exp Res. 2024. PMID: 39078432 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
