Autophagy in malignant transformation and cancer progression
- PMID: 25712477
- PMCID: PMC4388596
- DOI: 10.15252/embj.201490784
Autophagy in malignant transformation and cancer progression
Abstract
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
Keywords: Beclin 1; KRAS; adaptive stress responses; inflammation; mitophagy.
© 2015 The Authors.
Figures
Similar articles
-
The autophagic network and cancer.Nat Cell Biol. 2018 Mar;20(3):243-251. doi: 10.1038/s41556-018-0042-2. Epub 2018 Feb 23. Nat Cell Biol. 2018. PMID: 29476153 Review.
-
Oncosuppressive functions of autophagy.Antioxid Redox Signal. 2011 Jun;14(11):2251-69. doi: 10.1089/ars.2010.3478. Epub 2010 Dec 4. Antioxid Redox Signal. 2011. PMID: 20712403 Review.
-
Molecular machinery of autophagy and its implication in cancer.Am J Med Sci. 2012 Feb;343(2):155-161. doi: 10.1097/MAJ.0b013e31821f978d. Am J Med Sci. 2012. PMID: 21709535 Review.
-
The Evolving, Multifaceted Roles of Autophagy in Cancer.Adv Cancer Res. 2016;130:1-53. doi: 10.1016/bs.acr.2016.01.005. Epub 2016 Feb 23. Adv Cancer Res. 2016. PMID: 27037750 Review.
-
Autophagy in tumorigenesis and cancer treatment.Asian Pac J Cancer Prev. 2015;16(6):2167-75. doi: 10.7314/apjcp.2015.16.6.2167. Asian Pac J Cancer Prev. 2015. PMID: 25824733 Review.
Cited by
-
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy.Cell Death Differ. 2024 May 23. doi: 10.1038/s41418-024-01314-5. Online ahead of print. Cell Death Differ. 2024. PMID: 38783090
-
LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance.Int J Biol Sci. 2024 Apr 29;20(7):2698-2726. doi: 10.7150/ijbs.91832. eCollection 2024. Int J Biol Sci. 2024. PMID: 38725864 Free PMC article. Review.
-
Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview.Front Pharmacol. 2024 Apr 8;15:1375585. doi: 10.3389/fphar.2024.1375585. eCollection 2024. Front Pharmacol. 2024. PMID: 38650627 Free PMC article. Review.
-
The impact of nanomaterials on autophagy across health and disease conditions.Cell Mol Life Sci. 2024 Apr 17;81(1):184. doi: 10.1007/s00018-024-05199-y. Cell Mol Life Sci. 2024. PMID: 38630152 Free PMC article. Review.
-
Polyploidy and mTOR signaling: a possible molecular link.Cell Commun Signal. 2024 Mar 27;22(1):196. doi: 10.1186/s12964-024-01526-9. Cell Commun Signal. 2024. PMID: 38539200 Free PMC article. Review.
References
-
- Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, Kim SS, Yoo NJ, Lee SH. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS. 2007;115:1344–1349. - PubMed
-
- Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics. 1999;59:59–65. - PubMed
-
- Anderson MA, Huang D, Roberts A. Targeting BCL2 for the treatment of lymphoid malignancies. Semin Hematol. 2014;51:219–227. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous