Altered gray matter density and disrupted functional connectivity of the amygdala in adults with Internet gaming disorder
- PMID: 25448779
- DOI: 10.1016/j.pnpbp.2014.11.003
Altered gray matter density and disrupted functional connectivity of the amygdala in adults with Internet gaming disorder
Abstract
Objectives: The aim of this study was to evaluate the altered brain structure and functional connectivity (FC) among subjects with Internet gaming disorder (IGD).
Methods: We recruited 30 males with IGD and 30 controls and evaluated their gray matter density (GMD) and FC using resting fMRI. The severities of IGD, gaming urge, and impulsivity were also assessed.
Results: The results demonstrated that the subjects with IGD had a higher impulsivity and a greater severity of IGD. The subjects with IGD had a lower GMD over the bilateral amygdala than the controls. Further, the subjects with IGD had lower FC with the left amygdala over the left dorsolateral prefrontal lobe (DLPFC) and with the right amygdala over the left DLPFC and orbital frontal lobe (OFL). They also had higher FC with the bilateral amygdala over the contralateral insula than the controls. The FC between the left amygdala and DLPFC was negatively correlated with impulsivity. The FC of the right amygdala to the left DLPFC and orbital frontal lobe was also negatively correlated with impulsivity. Our results indicated that the altered GMD over the amygdala might represent vulnerability to IGD, such as impulsivity. Further analysis of the amygdala demonstrated impaired FC to the frontal lobe, which represents impulsivity.
Conclusion: The results of this study suggested that the amygdala plays a very influential role in the mechanism of IGD. Its detailed role should be further evaluated in future study and should be considered in the treatment of IGD.
Keywords: Amygdala; Functional connectivity; Gray matter; Impulsivity; Internet gaming disorder.
Copyright © 2014 Elsevier Inc. All rights reserved.
Similar articles
-
Altered Functional Connectivity of the Insula and Nucleus Accumbens in Internet Gaming Disorder: A Resting State fMRI Study.Eur Addict Res. 2016;22(4):192-200. doi: 10.1159/000440716. Epub 2016 Feb 11. Eur Addict Res. 2016. PMID: 26863028
-
Abnormal gray matter volume and impulsivity in young adults with Internet gaming disorder.Addict Biol. 2018 Sep;23(5):1160-1167. doi: 10.1111/adb.12552. Epub 2017 Sep 8. Addict Biol. 2018. PMID: 28884950
-
The Correlation between the Frontostriatal Network and Impulsivity in Internet Gaming Disorder.Sci Rep. 2019 Feb 4;9(1):1191. doi: 10.1038/s41598-018-37702-4. Sci Rep. 2019. PMID: 30718701 Free PMC article.
-
The prefrontal dysfunction in individuals with Internet gaming disorder: a meta-analysis of functional magnetic resonance imaging studies.Addict Biol. 2015 Jul;20(4):799-808. doi: 10.1111/adb.12154. Epub 2014 Jun 3. Addict Biol. 2015. PMID: 24889021 Review.
-
Neurobiological correlates of internet gaming disorder: Similarities to pathological gambling.Addict Behav. 2017 Jan;64:349-356. doi: 10.1016/j.addbeh.2015.11.004. Epub 2015 Nov 24. Addict Behav. 2017. PMID: 26621112 Review.
Cited by
-
Heart Rate Variability during Online Video Game Playing in Habitual Gamers: Effects of Internet Addiction Scale, Ranking Score and Gaming Performance.Brain Sci. 2023 Dec 26;14(1):29. doi: 10.3390/brainsci14010029. Brain Sci. 2023. PMID: 38248244 Free PMC article.
-
High-dimensional Metaverse Platforms and the Virtually Extended Self.J Cogn. 2024 Jan 9;7(1):2. doi: 10.5334/joc.327. eCollection 2024. J Cogn. 2024. PMID: 38223229 Free PMC article.
-
Meta-analysis of structural and functional brain alterations in internet gaming disorder.Front Psychiatry. 2022 Oct 25;13:1029344. doi: 10.3389/fpsyt.2022.1029344. eCollection 2022. Front Psychiatry. 2022. PMID: 37033880 Free PMC article.
-
Graph analysis of diffusion tensor imaging-based connectome in young men with internet gaming disorder.Front Neurosci. 2023 Jan 30;16:1090224. doi: 10.3389/fnins.2022.1090224. eCollection 2022. Front Neurosci. 2023. PMID: 36798605 Free PMC article.
-
Structural and Functional Neural Alterations in Internet Addiction: A Study Protocol for Systematic Review and Meta-Analysis.Psychiatry Investig. 2023 Jan;20(1):69-74. doi: 10.30773/pi.2021.0383. Epub 2023 Jan 25. Psychiatry Investig. 2023. PMID: 36721888 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources