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Review
. 2015 Jan;17(1):23-8.
doi: 10.1111/hpb.12308. Epub 2014 Jul 3.

Liver transplantation for neuroendocrine tumour liver metastases

Sheung Tat Fan  1 , Yves Patrice Le Treut, Vincenzo Mazzaferro, Andrew K Burroughs, Michael Olausson, Stefan Breitenstein, Andrea Frilling
Affiliations
Review

Liver transplantation for neuroendocrine tumour liver metastases

Sheung Tat Fan et al. HPB (Oxford). 2015 Jan.

Abstract

Objective: Search and review of available literature were made to define the indications for and timing of liver transplantation for neuroendocrine tumour (NET) liver metastases.

Methods: Electronic bibliographical databases were searched. Prospective and retrospective cohort studies and case-controlled studies were used for qualitative and quantitative synthesis of the systematic review. Reports of patients with liver transplantation alone for NET liver metastases of any origin or combined with resection of extrahepatic tumour deposits were recruited.

Results: The number of patients who have undergone liver transplantation for NET liver metastases is 706. The post-transplant 5-year survival rate from the time of diagnosis was approximately 70%. NET patients with metastases confined to the liver and not poorly differentiated are favourable candidates for liver transplantation. Selection of patients based on evolution of tumours over 6 months is not recommended.

Conclusion: Non-resectable NET liver metastasis resistant to medical treatment and confined to the liver is an accepted indication for liver transplantation.

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Figures

Figure 1
Figure 1
Flow diagram demonstrating retrieval of reports of neuroendocrine tumour liver-metastases from the literature
Figure 2
Figure 2
Benefit of liver transplantation for neuroendocrine tumour (NET) metastases in liver
See this image and copyright information in PMC

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References

    1. Gedaly R, Daily MF, Davenport D, McHuge PP, Koch A, Angulo P, et al. Liver transplantation for the treatment of liver metastases from neuroendocrine tumours – an analysis of the UNOS database. Arch Surg. 2011;146:953–958. - PubMed
    1. Burra P, Germani G, Adam R, Karam V, Marzano A, Lampertico P, et al. Liver transplantation for HBV-related cirrhosis in Europe: an ELTR study on evolution and outcomes. J Hepatol. 2013;58:287–296. - PubMed
    1. Stump R, Haueis S, Kalt N, Tschuor C, Limani P, Lesurtel M, et al. Transplant and surgical strategies in patients with NET liver metastases – a protocol of four systematic reviews. JMIR Res Protoc. 2013;2:e58. - PMC - PubMed
    1. Nguyen NT, Harring TR, Goss JA, O'Mahony CA. Neuroendocrine liver metastases and orthotopic liver transplantation: the US experience. Int J Hepatol. 2011;2011:742890. - PMC - PubMed
    1. Frilling A, Li J, Malamutmann E, Schmid K-W, Bockisch A, Broelsch CE. Treatment of liver metastases from neuroendocrine tumours in relation to the extent of hepatic disease. Br J Surg. 2009;96:175–184. - PubMed