Clinical Trial

. 2014 May 27;129(21):2094-9.

doi: 10.1161/CIRCULATIONAHA.113.007825. Epub 2014 Mar 14.

Temporal relationship between subclinical atrial fibrillation and embolic events

Michela Brambatti¹, Stuart J Connolly¹, Michael R Gold¹, Carlos A Morillo¹, Alessandro Capucci¹, Carmine Muto¹, Chu P Lau¹, Isabelle C Van Gelder¹, Stefan H Hohnloser¹, Mark Carlson¹, Eric Fain¹, Juliet Nakamya¹, Georges H Mairesse¹, Marta Halytska¹, Wei Q Deng¹, Carsten W Israel¹, Jeff S Healey²; ASSERT Investigators

Affiliations

¹ From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center Groningen, Groningen, Netherlands (I.C.V.G.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); St Jude Medical, Sylmar, CA, and Zaventem, Belgium (M.C.); Clinique du Sud Luxembourg, Arlon, Belgium (G.H.M.); and Evangelical Hospital Bielefeld, Department of Medicine, Division of Cardiology, Bielefeld, Germany (C.W.I.).
² From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center Groningen, Groningen, Netherlands (I.C.V.G.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); St Jude Medical, Sylmar, CA, and Zaventem, Belgium (M.C.); Clinique du Sud Luxembourg, Arlon, Belgium (G.H.M.); and Evangelical Hospital Bielefeld, Department of Medicine, Division of Cardiology, Bielefeld, Germany (C.W.I.). Jeff.Healey@phri.ca.

PMID: 24633881
DOI: 10.1161/CIRCULATIONAHA.113.007825

Clinical Trial

Temporal relationship between subclinical atrial fibrillation and embolic events

Michela Brambatti et al. Circulation. 2014.

. 2014 May 27;129(21):2094-9.

doi: 10.1161/CIRCULATIONAHA.113.007825. Epub 2014 Mar 14.

Authors

Affiliations

¹ From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center Groningen, Groningen, Netherlands (I.C.V.G.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); St Jude Medical, Sylmar, CA, and Zaventem, Belgium (M.C.); Clinique du Sud Luxembourg, Arlon, Belgium (G.H.M.); and Evangelical Hospital Bielefeld, Department of Medicine, Division of Cardiology, Bielefeld, Germany (C.W.I.).
² From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center Groningen, Groningen, Netherlands (I.C.V.G.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); St Jude Medical, Sylmar, CA, and Zaventem, Belgium (M.C.); Clinique du Sud Luxembourg, Arlon, Belgium (G.H.M.); and Evangelical Hospital Bielefeld, Department of Medicine, Division of Cardiology, Bielefeld, Germany (C.W.I.). Jeff.Healey@phri.ca.

PMID: 24633881
DOI: 10.1161/CIRCULATIONAHA.113.007825

Abstract

Background: Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship.

Methods and results: The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker and defibrillator patients aged ≥65 years with a history of hypertension but without a history of atrial fibrillation. Pacemakers and implantable cardioverter-defibrillators precisely logged the time and duration of all episodes of SCAF and recorded electrograms that were adjudicated by experts. We examined the temporal relationship between SCAF >6 minutes in duration and stroke or systemic embolism. Of 51 patients who experienced stroke or systemic embolism during follow-up, 26 (51%) had SCAF. In 18 patients (35%), SCAF was detected before stroke or systemic embolism. However, only 4 patients (8%) had SCAF detected within 30 days before stroke or systemic embolism, and only 1 of these 4 patients was experiencing SCAF at the time of the stroke. In the 14 patients with SCAF detected >30 days before stroke or systemic embolism, the most recent episode occurred at a median interval of 339 days (25th to 75th percentile, 211-619) earlier. Eight patients (16%) had SCAF detected only after their stroke, despite continuous monitoring for a median duration of 228 days (25th to 75th percentile, 202-719) before their event.

Conclusions: Although SCAF is associated with an increased risk of stroke and embolism, very few patients had SCAF in the month before their event.

Clinical trial registration url: http://www.clinicaltrials.gov. Unique identifier: NCT00256152.

Keywords: arrhythmia; pacemaker; stroke.

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Comment in

Letter by Haft regarding article, "Temporal relationship between subclinical atrial fibrillation and embolic events".
Haft JI. Haft JI. Circulation. 2015 Feb 3;131(5):e336. doi: 10.1161/CIRCULATIONAHA.114.011693. Circulation. 2015. PMID: 25645617 No abstract available.
Response to letter regarding article "Temporal relationship between subclinical atrial fibrillation and embolic events".
Healey JS, Brambatti M, Gold MR, Morillo CA, Capucci A, Muto C, Lau CP, Van Gelder IC, Hohnloser SH, Carlson M, Fain E, Nakamya J, Mairesse GH, Halytska M, Deng WQ, Israel CW, Connolly SJ; ASSERT Investigators. Healey JS, et al. Circulation. 2015 Feb 3;131(5):e337-8. doi: 10.1161/CIRCULATIONAHA.114.012885. Circulation. 2015. PMID: 25645618 No abstract available.

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Temporal relationship between subclinical atrial fibrillation and embolic events

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Temporal relationship between subclinical atrial fibrillation and embolic events

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