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Comparative Study
. 2014 May;35(5):1072-86.
doi: 10.1016/j.ridd.2014.01.032. Epub 2014 Mar 12.

Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder

Angela John Thurman  1 , Andrea McDuffie  2 , Randi Hagerman  3 , Leonard Abbeduto  2
Affiliations
Comparative Study

Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder

Angela John Thurman et al. Res Dev Disabil. 2014 May.

Abstract

In the present study, we examined the profile of psychiatric symptoms in boys with fragile X syndrome (FXS) using a parent report instrument. In addition, by comparing boys with FXS to boys with nonsyndromic autism spectrum disorder (ASD) utilizing multiple matching strategies, we examined between-group differences in the types of psychiatric symptoms observed and in the strength of their concurrent associations. Across all matching strategies, symptoms of manic/hyperactive behaviors and general anxiety were more frequently reported for boys with FXS than for boys with nonsyndromic ASD. Results also indicated a positive association between social avoidance and general anxiety in FXS that was stronger than that observed in nonsyndromic ASD across all matching strategies. Theoretical and treatment implications are discussed.

Keywords: Anxiety; Autism spectrum disorder; Fragile X syndrome; Hyperactivity; Psychiatric symptoms; Social avoidance.

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Figures

Figure 1
Figure 1
Maternal mean ratings on ADAMS subscales as a function of diagnostic group for Full Sample matched on CA.
Figure 2
Figure 2
Maternal mean ratings on ADAMS subscales as a function of diagnostic group for CA-NVIQ Matched Sample.
Figure 3
Figure 3
Maternal Mean ratings on ADAMS subscales as a function of diagnostic group for CA-NVIQ-Autism Symptom Severity Matched Sample.
See this image and copyright information in PMC

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