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. 2014 Apr;30(2):191-7.
doi: 10.1007/s12264-013-1419-7. Epub 2014 Mar 6.

MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease

Ning Tian  1 , Zeyuan Cao, Yan Zhang
Affiliations

MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease

Ning Tian et al. Neurosci Bull. 2014 Apr.

Abstract

MicroRNA alterations have been reported in patients with Alzheimer's disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.

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