Structural brain development and depression onset during adolescence: a prospective longitudinal study
- PMID: 24577365
- DOI: 10.1176/appi.ajp.2013.13070920
Structural brain development and depression onset during adolescence: a prospective longitudinal study
Abstract
Objective: The authors sought to investigate whether the structural development of limbic, striatal, and prefrontal regions that are critically implicated in the pathophysiology of depression is associated with adolescent-onset depression.
Method: In a longitudinal design, a risk enriched community sample of 86 adolescents (41 of them female) who had no history of depressive disorders participated in neuroimaging assessments conducted during early (age 12) and midadolescence (age 16). Onset of depressive disorders was assessed for the period spanning early to late adolescence (ages 12 to 18). Thirty participants experienced a first episode of a depressive disorder during the follow-up period. The authors assessed whether onset of depressive disorder was associated with structural change in limbic, striatal, and prefrontal cortical regions from early to mid-adolescence.
Results: Volumetric change in the hippocampus, amygdala, and putamen from early to mid-adolescence was associated with the onset of depression during adolescence. Attenuated growth of the hippocampus and attenuated reduction in putamen volume over time were associated with the onset of depression. Sex moderated the association between amygdala growth and depression such that exaggerated growth and attenuated growth of the amygdala were associated with depression in females and males, respectively. Across time, smaller nucleus accumbens volume was associated with depression in females only.
Conclusions: These findings suggest that alterations in the developmental trajectories of limbic and striatal regions during adolescence may represent a neurobiological manifestation of a risk factor for the development of depression during this critical period and thus may provide clues as to etiological mechanisms of this disorder.
Comment in
-
Toward mapping altered trajectories of brain development in depression.Am J Psychiatry. 2014 May;171(5):489-91. doi: 10.1176/appi.ajp.2014.14020191. Am J Psychiatry. 2014. PMID: 24788279 No abstract available.
Similar articles
-
Early Childhood Depression and Alterations in the Trajectory of Gray Matter Maturation in Middle Childhood and Early Adolescence.JAMA Psychiatry. 2016 Jan;73(1):31-8. doi: 10.1001/jamapsychiatry.2015.2356. JAMA Psychiatry. 2016. PMID: 26676835 Free PMC article.
-
Brain Structural Signatures of Adolescent Depressive Symptom Trajectories: A Longitudinal Magnetic Resonance Imaging Study.J Am Acad Child Adolesc Psychiatry. 2017 Jul;56(7):593-601.e9. doi: 10.1016/j.jaac.2017.05.008. Epub 2017 May 15. J Am Acad Child Adolesc Psychiatry. 2017. PMID: 28647011
-
Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression.Psychol Med. 2015 Apr;45(5):1001-9. doi: 10.1017/S0033291714002001. Epub 2014 Aug 27. Psychol Med. 2015. PMID: 25162634
-
Stress, sensitive periods and maturational events in adolescent depression.Trends Neurosci. 2008 Apr;31(4):183-91. doi: 10.1016/j.tins.2008.01.004. Epub 2008 Mar 10. Trends Neurosci. 2008. PMID: 18329735 Review.
-
[The anatomy of depression in light of evidence from neuroimaging studies].Psychiatr Pol. 2008 Nov-Dec;42(6):875-88. Psychiatr Pol. 2008. PMID: 19441665 Review. Polish.
Cited by
-
Sex differences in plasma proteomic markers in late-life depression.Psychiatry Res. 2024 Apr;334:115773. doi: 10.1016/j.psychres.2024.115773. Epub 2024 Feb 7. Psychiatry Res. 2024. PMID: 38350292
-
A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence.Brain Imaging Behav. 2024 Jun;18(3):519-528. doi: 10.1007/s11682-023-00847-6. Epub 2024 Jan 13. Brain Imaging Behav. 2024. PMID: 38216837 Free PMC article.
-
Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.Biol Psychiatry Glob Open Sci. 2023 Oct 14;4(1):61-72. doi: 10.1016/j.bpsgos.2023.10.002. eCollection 2024 Jan. Biol Psychiatry Glob Open Sci. 2023. PMID: 38076598 Free PMC article.
-
Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens.Psychol Med. 2024 Apr;54(5):1045-1056. doi: 10.1017/S0033291723002866. Epub 2023 Sep 26. Psychol Med. 2024. PMID: 37750294 Free PMC article.
-
Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Curr Neuropharmacol. 2024;22(5):935-962. doi: 10.2174/1570159X21666230703091435. Curr Neuropharmacol. 2024. PMID: 37403395 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical