Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort
- PMID: 24408213
- DOI: 10.1007/s00213-013-3427-8
Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort
Abstract
Rationale and objective: Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments.
Methods: We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available n = 1,075).
Results: A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [F(2, 1,063) = 7.2, p < 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption.
Conclusion: Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.
Similar articles
-
Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study.Psychopharmacology (Berl). 2011 May;215(1):13-22. doi: 10.1007/s00213-010-2109-z. Epub 2010 Dec 8. Psychopharmacology (Berl). 2011. PMID: 21140256
-
Family Relationships and Alcohol Consumption: Interaction with the Serotonin Transporter Promoter Polymorphism (5-HTTLPR).Neuropsychobiology. 2022;81(6):497-505. doi: 10.1159/000526004. Epub 2022 Aug 23. Neuropsychobiology. 2022. PMID: 35998564
-
Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism.Biol Psychiatry. 2009 Jul 15;66(2):102-9. doi: 10.1016/j.biopsych.2009.02.010. Epub 2009 Apr 9. Biol Psychiatry. 2009. PMID: 19358979
-
Personality and the serotonin transporter gene: Associations in a longitudinal population-based study.Biol Psychol. 2009 Apr;81(1):9-13. doi: 10.1016/j.biopsycho.2009.01.001. Biol Psychol. 2009. PMID: 19437595
-
The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study.Prog Neuropsychopharmacol Biol Psychiatry. 2011 Dec 1;35(8):1857-62. doi: 10.1016/j.pnpbp.2011.08.004. Epub 2011 Aug 12. Prog Neuropsychopharmacol Biol Psychiatry. 2011. PMID: 21864630
Cited by
-
To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.Neuropsychobiology. 2024;83(1):41-48. doi: 10.1159/000535912. Epub 2024 Jan 16. Neuropsychobiology. 2024. PMID: 38228118 Free PMC article.
-
Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning.Psychopharmacology (Berl). 2022 Oct;239(10):3355-3366. doi: 10.1007/s00213-022-06228-z. Epub 2022 Sep 5. Psychopharmacology (Berl). 2022. PMID: 36063206
-
Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol.Psychopharmacology (Berl). 2022 Oct;239(10):3145-3159. doi: 10.1007/s00213-022-06195-5. Epub 2022 Aug 8. Psychopharmacology (Berl). 2022. PMID: 35939082 Free PMC article.
-
Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice.Psychopharmacology (Berl). 2021 Jan;238(1):215-225. doi: 10.1007/s00213-020-05670-1. Epub 2020 Oct 4. Psychopharmacology (Berl). 2021. PMID: 33011817
-
Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.Acta Med Litu. 2018;25(1):7-13. doi: 10.6001/actamedica.v25i1.3698. Acta Med Litu. 2018. PMID: 29928152 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous