Review

. 2014 Jan;15(1):e8-21.

doi: 10.1016/S1470-2045(13)70362-0.

Recommendations for management of patients with neuroendocrine liver metastases

Andrea Frilling¹, Irvin M Modlin², Mark Kidd³, Christopher Russell⁴, Stefan Breitenstein⁵, Riad Salem⁶, Dik Kwekkeboom⁷, Wan-yee Lau⁸, Catherine Klersy⁹, Valerie Vilgrain¹⁰, Brian Davidson⁴, Mark Siegler¹¹, Martyn Caplin¹², Enrico Solcia⁹, Richard Schilsky¹³; Working Group on Neuroendocrine Liver Metastases

Collaborators, Affiliations

Collaborators

Working Group on Neuroendocrine Liver Metastases:
R Adam, G Akerstrom, J Belghiti, S Breitenstein, P-A Clavien, A Frilling, B Gustafsson, E Krenning, I M Modlin, J Norton, K Öberg, G Poston, P Ruszniewski, P Tait, G Toogood, C Russell, C Bouvier, A Jarecki, C Klersy, W-J Lau, M Siegler, B Gustafsson, G Rindi, M Kidd, K Öberg, V Vilgrain, R P Baum, N Heaton, G Poston, J Garden, S T Fan, T Van Gulik, A Sipperstein, P Ruszniewski, D Kwekkeboom, M Caplin, B Gustafsson, B Lawrence, W de Herder, T Ito, I M Modlin, G Rindi, A Perren, B Davidson, D S Klimstra, G Kloppel, M Kidd, A Scarpa, T Meyer, A Knuth, H Chen, K Öberg, E Van Cutsem, M E Pavel, B Kos-Kudla, K Conlon, V Vilgrain, M Imamura, G Kaltsas, D Broering, B Wiedenmann, R P Baum, A Al-Nahhas, P Lodge, M Cosimelli, G Grazi, N Heaton, L H Tang, R Salazar, A B Grossman, C Dejong, G Gores, G Poston, D M Nagorney, V Mazzaferro, R Jensen, M Lesurtel, J Garden, M Falconi, P Hellmann, D O'Toole, S T Fan, M Olauson, Y Le Treut, A K Burroughs, V Mazzaferro, T Van Gulik, J Valle, R Kianmanesch, A Sowa-Staszczak, A Sipperstein, M Milicevic, R Lencioni, J Ramage, B Sangro, P Ruszniewski, A Kennedy, L Bester, R Salem, R Sharma, R Parks, D Kwekkeboom, L Bodei, J Muller-Brand, L Kvols, D Manas, M Caplin, J Ramos, M E Pavel, H Wasan

Affiliations

¹ Imperial College London, London, UK.
² Yale University, New Haven, Connecticut, USA. Electronic address: imodlin@optonline.net.
³ Yale University, New Haven, Connecticut, USA.
⁴ University College London, London, UK.
⁵ University Hospital of Zurich, Zurich, Switzerland.
⁶ Northwestern University Chicago, Chicago, USA.
⁷ Erasmus Medical Center, Rotterdam, Netherlands.
⁸ Chinese University of Hong Kong, Hong Kong, China.
⁹ IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
¹⁰ Hôpital Beaujon, Clichy, Paris, France.
¹¹ University of Chicago, Chicago, USA.
¹² University College London, London, UK; Royal Free Hospital, London, UK.
¹³ American Society of Clinical Oncology, Alexandria, VA, USA.

PMID: 24384494
DOI: 10.1016/S1470-2045(13)70362-0

Review

Recommendations for management of patients with neuroendocrine liver metastases

Andrea Frilling et al. Lancet Oncol. 2014 Jan.

. 2014 Jan;15(1):e8-21.

doi: 10.1016/S1470-2045(13)70362-0.

Authors

Collaborators

Working Group on Neuroendocrine Liver Metastases:
R Adam, G Akerstrom, J Belghiti, S Breitenstein, P-A Clavien, A Frilling, B Gustafsson, E Krenning, I M Modlin, J Norton, K Öberg, G Poston, P Ruszniewski, P Tait, G Toogood, C Russell, C Bouvier, A Jarecki, C Klersy, W-J Lau, M Siegler, B Gustafsson, G Rindi, M Kidd, K Öberg, V Vilgrain, R P Baum, N Heaton, G Poston, J Garden, S T Fan, T Van Gulik, A Sipperstein, P Ruszniewski, D Kwekkeboom, M Caplin, B Gustafsson, B Lawrence, W de Herder, T Ito, I M Modlin, G Rindi, A Perren, B Davidson, D S Klimstra, G Kloppel, M Kidd, A Scarpa, T Meyer, A Knuth, H Chen, K Öberg, E Van Cutsem, M E Pavel, B Kos-Kudla, K Conlon, V Vilgrain, M Imamura, G Kaltsas, D Broering, B Wiedenmann, R P Baum, A Al-Nahhas, P Lodge, M Cosimelli, G Grazi, N Heaton, L H Tang, R Salazar, A B Grossman, C Dejong, G Gores, G Poston, D M Nagorney, V Mazzaferro, R Jensen, M Lesurtel, J Garden, M Falconi, P Hellmann, D O'Toole, S T Fan, M Olauson, Y Le Treut, A K Burroughs, V Mazzaferro, T Van Gulik, J Valle, R Kianmanesch, A Sowa-Staszczak, A Sipperstein, M Milicevic, R Lencioni, J Ramage, B Sangro, P Ruszniewski, A Kennedy, L Bester, R Salem, R Sharma, R Parks, D Kwekkeboom, L Bodei, J Muller-Brand, L Kvols, D Manas, M Caplin, J Ramos, M E Pavel, H Wasan

Affiliations

¹ Imperial College London, London, UK.
² Yale University, New Haven, Connecticut, USA. Electronic address: imodlin@optonline.net.
³ Yale University, New Haven, Connecticut, USA.
⁴ University College London, London, UK.
⁵ University Hospital of Zurich, Zurich, Switzerland.
⁶ Northwestern University Chicago, Chicago, USA.
⁷ Erasmus Medical Center, Rotterdam, Netherlands.
⁸ Chinese University of Hong Kong, Hong Kong, China.
⁹ IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
¹⁰ Hôpital Beaujon, Clichy, Paris, France.
¹¹ University of Chicago, Chicago, USA.
¹² University College London, London, UK; Royal Free Hospital, London, UK.
¹³ American Society of Clinical Oncology, Alexandria, VA, USA.

PMID: 24384494
DOI: 10.1016/S1470-2045(13)70362-0

Abstract

Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or targeted agents. A paucity of biological, molecular, and genomic information and an absence of data from rigorous trials limit the validity of many publications detailing management. This Review represents the views from an international conference, for which 15 expert working groups prepared evidence-based assessments addressing specific questions, and from which an independent jury derived final recommendations. The aim of the conference was to review the existing approaches to neuroendocrine liver metastases, assess the evidence on which management decisions were based, develop internationally acceptable recommendations for clinical practice (when evidence was available), and make recommendations for clinical and research endeavours. This report represents the final clinical statements and proposals for future research.

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Recommendations for management of patients with neuroendocrine liver metastases

Collaborators

Affiliations

Recommendations for management of patients with neuroendocrine liver metastases

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