Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
- PMID: 24382478
- DOI: 10.1016/j.bbadis.2013.12.011
Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases
Abstract
Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates.
Keywords: Misfolded proteins; Neurodegenerative diseases; Nrf2-ARE pathway; Oxidative stress.
Copyright © 2013. Published by Elsevier B.V.
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