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Meta-Analysis
. 2014 Feb 15:87:345-55.
doi: 10.1016/j.neuroimage.2013.11.001. Epub 2013 Nov 9.

Neural network of cognitive emotion regulation--an ALE meta-analysis and MACM analysis

N Kohn  1 , S B Eickhoff  2 , M Scheller  3 , A R Laird  4 , P T Fox  5 , U Habel  3
Affiliations
Meta-Analysis

Neural network of cognitive emotion regulation--an ALE meta-analysis and MACM analysis

N Kohn et al. Neuroimage. .

Erratum in

  • Neuroimage. 2015 May 1;111():631

Abstract

Cognitive regulation of emotions is a fundamental prerequisite for intact social functioning which impacts on both well being and psychopathology. The neural underpinnings of this process have been studied intensively in recent years, without, however, a general consensus. We here quantitatively summarize the published literature on cognitive emotion regulation using activation likelihood estimation in fMRI and PET (23 studies/479 subjects). In addition, we assessed the particular functional contribution of identified regions and their interactions using quantitative functional inference and meta-analytic connectivity modeling, respectively. In doing so, we developed a model for the core brain network involved in emotion regulation of emotional reactivity. According to this, the superior temporal gyrus, angular gyrus and (pre) supplementary motor area should be involved in execution of regulation initiated by frontal areas. The dorsolateral prefrontal cortex may be related to regulation of cognitive processes such as attention, while the ventrolateral prefrontal cortex may not necessarily reflect the regulatory process per se, but signals salience and therefore the need to regulate. We also identified a cluster in the anterior middle cingulate cortex as a region, which is anatomically and functionally in an ideal position to influence behavior and subcortical structures related to affect generation. Hence this area may play a central, integrative role in emotion regulation. By focusing on regions commonly active across multiple studies, this proposed model should provide important a priori information for the assessment of dysregulated emotion regulation in psychiatric disorders.

Keywords: ALE; Angular gyrus; DLPFC; Emotion regulation; MACM; SMA; STG; VLPFC; aMCC.

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Figures

Fig 1
Fig 1
Displayed are significant results from the meta-analysis of emotion regulation (cFWE corrected > .05).
Fig. 2
Fig. 2
Depicted are connectivity maps corrected for multiple comparisons (FWE > 0.05) for the IFG (a), the DLPFC (b), the aMCC (c), the (pre-)SMA (d), the STG (e) and the AG (f). Coactivation patterns are labeled red and seed VOI are in yellow.
Fig. 3
Fig. 3
This heuristic model of neural processing of emotion regulation relates to the modal model of emotion (Gross, 1998). Affective arousal is relayed via amygdala and basal ganglia to the VLPFC and the anterior insula, as well as SMA, angular gyrus and STG (a). The VLPFC initiates the appraisal and signals the need to regulate the emotion to the DLPFC (b). The DLFPC processes the regulation itself and gives a feedforward signal (via the aMCC or directly) to angular gyrus, SMA, STG, amygdala and basal ganglia, which in turn participate in the generation of a (regulated) emotional state (c).
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