The association between autism spectrum disorder and psychotic experiences in the Avon longitudinal study of parents and children (ALSPAC) birth cohort
- PMID: 23880491
- DOI: 10.1016/j.jaac.2013.05.010
The association between autism spectrum disorder and psychotic experiences in the Avon longitudinal study of parents and children (ALSPAC) birth cohort
Abstract
Objective: Studies report overlap between autism spectrum disorders and psychosis. This may indicate a relationship between the 2 disorders or an artificial overlap due to similarity of symptoms. The aim of this study was to investigate whether autism spectrum disorder and autistic traits predict psychotic experiences in early adolescence.
Method: This study analyzes prospective data from a cohort. A dataset was analyzed of 5,359 cohort members who had provided data on autistic traits and/or a diagnosis of an autism spectrum disorder and psychotic experiences at age 12 years.
Results: A diagnosis of an autism spectrum disorder (odds ratio = 2.81, 95% confidence interval = 1.07, 7.34 p = .035) and childhood autistic traits (odds ratio = 1.15, 95% confidence interval = 1.05, 1.26 p = .0018) were associated with psychotic experiences after adjustment for confounders.
Conclusions: These findings suggest a shared neurodevelopmental origin for autism and psychosis.
Keywords: Avon Longitudinal Study of Parents and Children (ALSPAC); autism spectrum disorder; birth cohort; longitudinal; psychotic experiences.
Copyright © 2013 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort.Schizophr Bull. 2023 Mar 15;49(2):364-374. doi: 10.1093/schbul/sbac167. Schizophr Bull. 2023. PMID: 36434745 Free PMC article.
-
Association of Trauma Type, Age of Exposure, and Frequency in Childhood and Adolescence With Psychotic Experiences in Early Adulthood.JAMA Psychiatry. 2019 Jan 1;76(1):79-86. doi: 10.1001/jamapsychiatry.2018.3155. JAMA Psychiatry. 2019. PMID: 30477014 Free PMC article.
-
The Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort as a resource for studying psychopathology in childhood and adolescence: a summary of findings for depression and psychosis.Soc Psychiatry Psychiatr Epidemiol. 2015 Jul;50(7):1017-27. doi: 10.1007/s00127-015-1072-8. Epub 2015 May 23. Soc Psychiatry Psychiatr Epidemiol. 2015. PMID: 26002411 Review.
-
"Autism-plus" spectrum disorders: intersection with psychosis and the schizophrenia spectrum.Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):609-27. doi: 10.1016/j.chc.2013.04.005. Epub 2013 Jun 18. Child Adolesc Psychiatr Clin N Am. 2013. PMID: 24012076 Review.
-
The association between early autistic traits and psychotic experiences in adolescence.Schizophr Res. 2012 Mar;135(1-3):164-9. doi: 10.1016/j.schres.2011.11.037. Epub 2012 Jan 13. Schizophr Res. 2012. PMID: 22245185
Cited by
-
Autism Spectrum Disorder and Early Psychosis: a narrative review from a neurodevelopmental perspective.Front Psychiatry. 2024 Mar 20;15:1362511. doi: 10.3389/fpsyt.2024.1362511. eCollection 2024. Front Psychiatry. 2024. PMID: 38571993 Free PMC article. Review.
-
Autism spectrum disorder, very-early onset schizophrenia, and child disintegrative disorder: the challenge of diagnosis. A case-report study.Front Psychiatry. 2023 Jul 28;14:1212687. doi: 10.3389/fpsyt.2023.1212687. eCollection 2023. Front Psychiatry. 2023. PMID: 37575588 Free PMC article.
-
Differential Diagnosis of ICD-11 Personality Disorder and Autism Spectrum Disorder in Adolescents.Children (Basel). 2023 Jun 1;10(6):992. doi: 10.3390/children10060992. Children (Basel). 2023. PMID: 37371224 Free PMC article.
-
Protocol for the development and testing of the schiZotypy Autism Questionnaire (ZAQ) in adults: a new screening tool to discriminate autism spectrum disorder from schizotypal disorder.BMC Psychiatry. 2023 Mar 28;23(1):200. doi: 10.1186/s12888-023-04690-3. BMC Psychiatry. 2023. PMID: 36978026 Free PMC article.
-
Practitioner Review: Psychosis in children and adolescents.J Child Psychol Psychiatry. 2023 Jul;64(7):980-988. doi: 10.1111/jcpp.13777. Epub 2023 Mar 6. J Child Psychol Psychiatry. 2023. PMID: 36878476 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical