Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2013 Oct;69(4):537-43.
doi: 10.1016/j.jaad.2013.04.063. Epub 2013 Jul 9.

Acute toxicity and risk of infection during total skin electron beam therapy for mycosis fungoides

Shane Lloyd  1 , Zhe Chen, Francine M Foss, Michael Girardi, Lynn D Wilson
Affiliations
Comparative Study

Acute toxicity and risk of infection during total skin electron beam therapy for mycosis fungoides

Shane Lloyd et al. J Am Acad Dermatol. 2013 Oct.

Abstract

Background: Detailed rates of acute toxicity and skin infection during total skin electron beam therapy (TSEBT) for mycosis fungoides have not been reported in a large, modern series.

Objective: We sought to demonstrate the rates of acute toxicity and skin infection during TSEBT.

Methods: We retrospectively reviewed 89 consecutive courses of TSEBT. In all, 82 courses were prescribed a dose of 30 to 36 Gy and were included in the toxicity analysis. We recorded the types and grades of acute treatment toxicities and the incidence of infection during TSEBT for comparison with the previously documented baseline incidence of infection in mycosis fungoides.

Results: The most common toxicities included erythema/desquamation (76%), blisters (52%), hyperpigmentation (50%), and skin pain (48%). The worst reported toxicity grade per patient was grade 1 in 21%, grade 2 in 67%, and grade 3 in 10%, with no grade 4 or 5 toxicities. According to the previously reported rate, a total of 2.4 infections were expected for our cohort at baseline. The number with skin infection was 26 (32%) (relative risk 10.8, P < .01), and of these, 12 (15%) were culture confirmed (relative risk 5.0, P < .01).

Limitations: This was a retrospective study design.

Conclusion: The risk of cutaneous infection is significant during TSEBT.

Keywords: AJCC; American Joint Committee on Cancer; ECP; MF; OR; RT; TSEBT; extracorporeal photopheresis; infection; mycosis fungoides; odds ratio; race; radiation therapy; total skin electron beam therapy; toxicity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

MeSH terms