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Review
. 2013 Jun 26:11:56.
doi: 10.1186/1477-7827-11-56.

Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Jun Z Qin  1 , Li H Pang, Mu J Li, Xiao J Fan, Ru D Huang, Hong Y Chen
Affiliations
Review

Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Jun Z Qin et al. Reprod Biol Endocrinol. .

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined.

Methods: Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University.

Results: A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49-4.74), PIH (OR3.43; 95% CI: 2.49-4.74), preeclampsia (OR2.17; 95% CI: 1.91-2.46), preterm birth (OR1.93; 95%CI: 1.45-2.57), caesarean section (OR 1.74; 95% CI: 1.38-2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD -0.11g; 95%CI: -0.19 - -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40-3.85) compared to controls.

Conclusions: Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.

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Figures

Figure 1
Figure 1
Flow diagram of included studies for this meta-analysis.
Figure 2
Figure 2
OR for incidence of GDM in women with PCOS and controls. 01 Incidence of GDM all studies included. 02 borderline eligible studies excluded.
Figure 3
Figure 3
OR for incidence of PIH in women with PCOS and controls. 01 Incidence of PIH all studies included. 02 borderline eligible studies excluded.
Figure 4
Figure 4
OR for incidence of PE in women with PCOS and controls. 01 Incidence PE all studies included. 02 borderline eligible studies excluded.
Figure 5
Figure 5
OR for incidence of preterm rate in women with PCOS and controls. 01 Preterm rate all studies included. 02 borderline eligible studies excluded.
Figure 6
Figure 6
WMD for birth weight in women with PCOS and controls. 01 Incidence of birth weight all studies included. 02 borderline eligible studies excluded.
Figure 7
Figure 7
OR for incidence of caesarean section in women with PCOS and controls. 01 Incidence of caesarean section all studies included. 02 borderline eligible studies excluded.
Figure 8
Figure 8
OR for incidence of admission to an NICU in women with PCOS and controls.
See this image and copyright information in PMC

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References

    1. Carmina E, Azziz R. Diagnosis, phenotype, and prevalence of polycystic ovary syndrome. Fertil Steril. 2006;86(Suppl 1):S7–S8. - PubMed
    1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod. 2004;19:41–47. - PubMed
    1. Lanzone A, Fulghesu AM, Cucinelli F, Guido M, Pavone V, Caruso A, Mancuso S. Preconceptional and gestational evaluation of insulin secretion in patients with polycystic ovary syndrome. Hum Reprod. 1996;11(11):2382–2386. doi: 10.1093/oxfordjournals.humrep.a019119. - DOI - PubMed
    1. Castelo-Branco C, Steinvarcel F, Osorio A, Ros C, Balasch J. Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol. 2010;26(10):736–742. doi: 10.3109/09513590.2010.481025. - DOI - PubMed
    1. Legro RS, Castracane VD, Kauffman RP. Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv. 2004;59(2):141–154. doi: 10.1097/01.OGX.0000109523.25076.E2. - DOI - PubMed