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. 2013 Jun 10;23(6):709-11.
doi: 10.1016/j.ccr.2013.05.015.

Succinate: a new epigenetic hacker

Ming Yang  1 , Patrick J Pollard
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Succinate: a new epigenetic hacker

Ming Yang et al. Cancer Cell. .
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Abstract

Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.

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  • SDH mutations establish a hypermethylator phenotype in paraganglioma.
    Letouzé E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, Janin M, Menara M, Nguyen AT, Benit P, Buffet A, Marcaillou C, Bertherat J, Amar L, Rustin P, De Reyniès A, Gimenez-Roqueplo AP, Favier J. Letouzé E, et al. Cancer Cell. 2013 Jun 10;23(6):739-52. doi: 10.1016/j.ccr.2013.04.018. Epub 2013 May 23. Cancer Cell. 2013. PMID: 23707781

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