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. 2013 Aug;148(1-3):87-92.
doi: 10.1016/j.schres.2013.05.015. Epub 2013 Jun 6.

Prenatal vitamin D status and risk of psychotic experiences at age 18years-a longitudinal birth cohort

Sarah Sullivan  1 , Andrew Wills, Debbie Lawlor, John McGrath, Stanley Zammit
Affiliations

Prenatal vitamin D status and risk of psychotic experiences at age 18years-a longitudinal birth cohort

Sarah Sullivan et al. Schizophr Res. 2013 Aug.

Abstract

Background: Low early life vitamin D status is associated with an increased risk of schizophrenia and psychotic experiences. Here we examine if maternal pregnancy vitamin D concentrations are associated with offspring psychotic experiences as young adults.

Methods: A community sample of 2047 participants was investigated. Maternal prenatal 25 hydroxyvitamin D (25(OH)D) concentrations were assessed with tandem mass spectroscopy. Psychotic experiences were assessed at age 18years using a semi-structured clinical interview.

Results: 177 cohort members reported suspected or definite psychotic experiences, There was no evidence of an association between maternal 25(OH)D concentrations as quartiles (p=0.85 hypothesis test of general association versus no association across the quartiles) or as a continuous variable (p=0.89) versus experience of suspected and definite psychotic experiences at 18years. Within the cohort, only 29 subjects met criteria for a psychotic disorder at age 18. Based on this sample, there was no significant association between maternal 25(OH)D and psychotic disorder at 18years.

Discussion: Maternal vitamin D levels were not associated with risk of psychotic experiences nor psychotic disorders in this birth cohort.

Keywords: 25-Hydroxyvitamin D; ALSPAC; Birth cohort; Pre-natal; Psychotic experiences.

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