Skip to main page content

Editorial

. 2013 Jun 27;368(26):2513-5.

doi: 10.1056/NEJMe1306743. Epub 2013 Jun 5.

Releasing the brake on puberty

PMID: 23738512
DOI: 10.1056/NEJMe1306743

Editorial

Releasing the brake on puberty

Ieuan A Hughes. N Engl J Med. 2013.

. 2013 Jun 27;368(26):2513-5.

doi: 10.1056/NEJMe1306743. Epub 2013 Jun 5.

Author

PMID: 23738512
DOI: 10.1056/NEJMe1306743

No abstract available

PubMed Disclaimer

Comment on

Central precocious puberty caused by mutations in the imprinted gene MKRN3.
Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Abreu AP, et al. N Engl J Med. 2013 Jun 27;368(26):2467-75. doi: 10.1056/NEJMoa1302160. Epub 2013 Jun 5. N Engl J Med. 2013. PMID: 23738509 Free PMC article.

Similar articles

Central precocious puberty: From genetics to treatment.
Aguirre RS, Eugster EA. Aguirre RS, et al. Best Pract Res Clin Endocrinol Metab. 2018 Aug;32(4):343-354. doi: 10.1016/j.beem.2018.05.008. Epub 2018 May 26. Best Pract Res Clin Endocrinol Metab. 2018. PMID: 30086862 Review.
A novel MKRN3 missense mutation causing familial precocious puberty.
de Vries L, Gat-Yablonski G, Dror N, Singer A, Phillip M. de Vries L, et al. Hum Reprod. 2014 Dec;29(12):2838-43. doi: 10.1093/humrep/deu256. Epub 2014 Oct 14. Hum Reprod. 2014. PMID: 25316453
New causes of central precocious puberty: the role of genetic factors.
Bulcao Macedo D, Nahime Brito V, Latronico AC. Bulcao Macedo D, et al. Neuroendocrinology. 2014;100(1):1-8. doi: 10.1159/000366282. Epub 2014 Aug 9. Neuroendocrinology. 2014. PMID: 25116033 Review.
MKRN3 and central precocious puberty.
Yaqub F. Yaqub F. Lancet Diabetes Endocrinol. 2013 Aug;1 Suppl 1:s15. doi: 10.1016/S2213-8587(13)70041-X. Epub 2013 Jun 13. Lancet Diabetes Endocrinol. 2013. PMID: 24622591 No abstract available.
Central precocious puberty caused by mutations in the imprinted gene MKRN3.
Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Abreu AP, et al. N Engl J Med. 2013 Jun 27;368(26):2467-75. doi: 10.1056/NEJMoa1302160. Epub 2013 Jun 5. N Engl J Med. 2013. PMID: 23738509 Free PMC article.

See all similar articles

Cited by

Novel MKRN3 Missense Mutations Associated With Central Precocious Puberty Reveal Distinct Effects on Ubiquitination.
Magnotto JC, Mancini A, Bird K, Montenegro L, Tütüncüler F, Pereira SA, Simas V, Garcia L, Roberts SA, Macedo D, Magnuson M, Gagliardi P, Mauras N, Witchel SF, Carroll RS, Latronico AC, Kaiser UB, Abreu AP. Magnotto JC, et al. J Clin Endocrinol Metab. 2023 Jun 16;108(7):1646-1656. doi: 10.1210/clinem/dgad151. J Clin Endocrinol Metab. 2023. PMID: 36916482 Free PMC article.
MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
Abreu AP, Toro CA, Song YB, Navarro VM, Bosch MA, Eren A, Liang JN, Carroll RS, Latronico AC, Rønnekleiv OK, Aylwin CF, Lomniczi A, Ojeda S, Kaiser UB. Abreu AP, et al. J Clin Invest. 2020 Aug 3;130(8):4486-4500. doi: 10.1172/JCI136564. J Clin Invest. 2020. PMID: 32407292 Free PMC article.
Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation.
Liu H, Kong X, Chen F. Liu H, et al. Oncotarget. 2017 Jul 18;8(49):85102-85109. doi: 10.18632/oncotarget.19347. eCollection 2017 Oct 17. Oncotarget. 2017. PMID: 29156706 Free PMC article.
Pubertal development and regulation.
Abreu AP, Kaiser UB. Abreu AP, et al. Lancet Diabetes Endocrinol. 2016 Mar;4(3):254-264. doi: 10.1016/S2213-8587(15)00418-0. Epub 2016 Feb 4. Lancet Diabetes Endocrinol. 2016. PMID: 26852256 Free PMC article. Review.
Continuation of gradual weight gain necessary for the onset of puberty may be responsible for obesity later in life.
Lehrer S. Lehrer S. Discov Med. 2015 Oct;20(110):191-6. Discov Med. 2015. PMID: 26562472 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Atypon
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations