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Randomized Controlled Trial
. 2013 Spring;25(2):126-33.
doi: 10.1176/appi.neuropsych.11110330.

Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?

Aimee M Hunter  1 , Alexander S Korb, Ian A Cook, Andrew F Leuchter
Affiliations
Randomized Controlled Trial

Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?

Aimee M Hunter et al. J Neuropsychiatry Clin Neurosci. 2013 Spring.

Abstract

High rostral anterior cingulate cortex (rACC) activity has been shown to predict antidepressant treatment response; however, it is unclear whether this is a fixed versus variable marker of responsiveness. The authors measured rACC theta current density in 22 subjects 5 weeks before and again immediately before 5 weeks of blinded treatment with sertraline. Mixed-effects regression analysis found that the relationship between response and rACC activity depended significantly on the timing of the rACC assessment; rACC activity measured immediately before treatment was a significantly better predictor of response. rACC activity may constitute a variable "state" indicator of responsiveness to antidepressants.

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