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. 2013 Sep;36(9):2850-6.
doi: 10.2337/dc12-2337. Epub 2013 May 1.

The atrial natriuretic peptide genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a Mediterranean population

Valentina Cannone  1 , Angelo Baldassare Cefalu', Davide Noto, Christopher G Scott, Kent R Bailey, Giovanni Cavera, Michele Pagano, Michelangelo Sapienza, Maurizio R Averna, John C Burnett Jr
Affiliations

The atrial natriuretic peptide genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a Mediterranean population

Valentina Cannone et al. Diabetes Care. 2013 Sep.

Abstract

Objective: We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population.

Research design and methods: We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068.

Results: Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m(2) [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95% CI 0.20-0.83], P = 0.01).

Conclusions: The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension and metabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.

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Figures

Figure 1
Figure 1
Systolic blood pressure values in the study population according to rs5068 genotypes. *P value obtained from logistic regression model adjusting for age, sex, BMI, and treatment for hypertension. Error bars represent 1 SD above the mean.
Figure 2
Figure 2
Prevalence of hypertension in the study population according to rs5068 genotypes. *P value obtained from logistic regression model adjusting for age, sex, and BMI.
Figure 3
Figure 3
BMI in the study population according to rs5068 genotypes. *P value obtained from logistic regression model adjusting for age and sex. Error bars represent 1 SD above the mean.
See this image and copyright information in PMC

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