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Review
. 2013 Sep;54(9):2307-14.
doi: 10.1194/jlr.R026641. Epub 2013 Mar 15.

Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection

Moshe Vardi  1 , Nina S Levy, Andrew P Levy
Affiliations
Review

Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection

Moshe Vardi et al. J Lipid Res. 2013 Sep.

Abstract

Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from observational epidemiological studies associating higher vitamin E dietary intake with lower risk of CV events have not been validated in randomized controlled clinical trials assessing the effect of vitamin E on CV outcomes. While the pendulum of medical opinion has swung to suggest that high dose vitamin E supplements have no place in the treatment and prevention of CV disease, new data is emerging that allows identification of a specific target population for this treatment, namely patients with diabetes mellitus and the haptoglobin genotype 2-2. This review details the scientific basis and clinical evidence related to the effect of vitamin E on CV outcomes, and the importance of proper patient selection in gaining therapeutic benefit from this intervention.

Keywords: cardiovascular outcomes; diabetes mellitus; haptoglobin.

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