Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C
- PMID: 2350187
- DOI: 10.1016/0003-9861(90)90508-v
Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C
Abstract
The oxidation of human low density lipoprotein (LDL) initiated by free radical initiator and its inhibition by vitamin E and water-soluble antioxidants have been studied. It was found that the kinetic chain length was considerably larger than 1, suggesting that LDL was oxidized by a free radical chain mechanism. Vitamin E acted as a lipophilic chain-breaking antioxidant. Water-soluble chain-breaking antioxidants such as ascorbic acid and uric acid suppressed the oxidation of LDL initiated by aqueous radicals but they could not scavenge lipophilic radicals within LDL to break the chain propagation. Ascorbic acid acted as a synergistic antioxidant in conjunction with vitamin E.
Similar articles
-
Effects of antioxidants on the oxidative susceptibility of low-density lipoprotein.J Nutr Sci Vitaminol (Tokyo). 1997 Aug;43(4):435-44. doi: 10.3177/jnsv.43.435. J Nutr Sci Vitaminol (Tokyo). 1997. PMID: 9328862
-
Dynamics of the oxidation of low density lipoprotein induced by free radicals.Biochim Biophys Acta. 1993 Jul 1;1168(3):348-57. Biochim Biophys Acta. 1993. PMID: 8323975
-
Inhibition of oxidative modification of low density lipoprotein by antioxidants.J Nutr Sci Vitaminol (Tokyo). 1993;39 Suppl:S1-8. doi: 10.3177/jnsv.39.supplement_s1. J Nutr Sci Vitaminol (Tokyo). 1993. PMID: 8164063 Review.
-
Lipid antioxidants: how they may act in biological systems.Br J Cancer Suppl. 1987 Jun;8:153-7. Br J Cancer Suppl. 1987. PMID: 3307868 Free PMC article. Review.
-
Membrane damage due to lipid oxidation.Am J Clin Nutr. 1991 Jan;53(1 Suppl):201S-205S. doi: 10.1093/ajcn/53.1.201S. Am J Clin Nutr. 1991. PMID: 1985388
Cited by
-
Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging Antioxidants.Antioxid Redox Signal. 2023 Oct;39(10-12):728-743. doi: 10.1089/ars.2022.0191. Epub 2023 Jun 23. Antioxid Redox Signal. 2023. PMID: 37154744 Free PMC article. Review.
-
Free Radical Chain Reactions and Polyunsaturated Fatty Acids in Brain Lipids.ACS Omega. 2022 Jul 14;7(29):25337-25345. doi: 10.1021/acsomega.2c02285. eCollection 2022 Jul 26. ACS Omega. 2022. PMID: 35910174 Free PMC article.
-
Possible Biochemical Processes Underlying the Positive Health Effects of Plant-Based Diets-A Narrative Review.Nutrients. 2021 Jul 28;13(8):2593. doi: 10.3390/nu13082593. Nutrients. 2021. PMID: 34444753 Free PMC article. Review.
-
A Novel Vitamin E TPGS-Based Formulation Enhances Chlorhexidine Bioavailability in Corneal Layers.Pharmaceutics. 2020 Jul 8;12(7):642. doi: 10.3390/pharmaceutics12070642. Pharmaceutics. 2020. PMID: 32650410 Free PMC article.
-
Nutritional and medical food therapies for diabetic retinopathy.Eye Vis (Lond). 2020 Jun 18;7:33. doi: 10.1186/s40662-020-00199-y. eCollection 2020. Eye Vis (Lond). 2020. PMID: 32582807 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical