Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jan 14;23(1):35-47.
doi: 10.1016/j.ccr.2012.11.010. Epub 2012 Dec 20.

The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man

Naomi L Sharma  1 , Charlie E Massie, Antonio Ramos-Montoya, Vincent Zecchini, Helen E Scott, Alastair D Lamb, Stewart MacArthur, Rory Stark, Anne Y Warren, Ian G Mills, David E Neal
Affiliations
Free article

The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man

Naomi L Sharma et al. Cancer Cell. .
Free article

Abstract

The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive analysis of AR binding sites in human prostate cancer tissues, including castrate-resistant prostate cancer (CRPC). We identified thousands of AR binding sites in CRPC tissue, most of which were not identified in PC cell lines. Many adjacent genes showed AR regulation in xenografts but not in cultured LNCaPs, demonstrating an in-vivo-restricted set of AR-regulated genes. Functional studies support a model of altered signaling in vivo that directs AR binding. We identified a 16 gene signature that outperformed a larger in-vitro-derived signature in clinical data sets, showing the importance of persistent AR signaling in CRPC.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Associated data