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Randomized Controlled Trial
. 2012 Sep 27:13:90.
doi: 10.1186/1471-2350-13-90.

Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

Carolina Bonilla  1 , Debbie A Lawlor, Yoav Ben-Shlomo, Andrew R Ness, David Gunnell, Susan M Ring, George Davey Smith, Sarah J Lewis
Affiliations
Randomized Controlled Trial

Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

Carolina Bonilla et al. BMC Med Genet. .

Abstract

Background: In observational epidemiological studies type 2 diabetes (T2D) and both low and high plasma concentrations of fasting glucose have been found to be associated with lower cognitive performance. These associations could be explained by confounding.

Methods: In this study we looked at the association between genetic variants, known to be robustly associated with fasting glucose and T2D risk, in the mother and her offspring to determine whether there is likely to be a causal link between early life exposure to glucose and child's intelligence quotient (IQ) scores in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. We generated a fasting glucose (FGGRS) and a T2D (T2DGRS) genetic risk score and used them in a Mendelian randomization approach.

Results: We found a strong correlation between the FGGRS and fasting glucose plasma measurements that were available for a subset of children, but no association of either the maternal or the offspring FGGRS with child's IQ was observed. In contrast, the maternal T2DGRS was positively associated with offspring IQ.

Conclusions: Maternal and offspring genetic variants which are associated with glucose levels are not associated with offspring IQ, suggesting that there is unlikely to be a causal link between glucose exposure in utero and IQ in childhood. Further exploration in even larger cohorts is required to exclude the possibility that our null findings were due to a lack of statistical power.

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Figures

Figure 1
Figure 1
Flow-diagram of participants in the study and reasons for exclusions.
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References

    1. Benton D. Vitamins and neural and cognitive developmental outcomes in children. Proc Nutr Soc. 2012;71:14–26. doi: 10.1017/S0029665111003247. - DOI - PubMed
    1. Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr. 2007;85:614S–620S. - PubMed
    1. Donohoe RT, Benton D. Cognitive functioning is susceptible to the level of blood glucose. Psychopharmacology. 1999;145:378–385. doi: 10.1007/s002130051071. - DOI - PubMed
    1. Craft S, Newcomer J, Kanne S. et al.Memory improvement following induced hyperinsulinemia in Alzheimer’s disease. Neurobiol Aging. 1996;17:123–130. doi: 10.1016/0197-4580(95)02002-0. - DOI - PubMed
    1. Baumann MU, Deborde S, Illsley NP. Placental glucose transfer and fetal growth. Endocrine. 2002;19:13–22. doi: 10.1385/ENDO:19:1:13. - DOI - PubMed

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