Obesity and appetite control
- PMID: 22899902
- PMCID: PMC3415214
- DOI: 10.1155/2012/824305
Obesity and appetite control
Abstract
Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity. Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. The hypothalamus is a key region which possesses reciprocal connections between the higher cortical centres such as reward-related limbic pathways, and the brainstem. Furthermore, the hypothalamus integrates a number of peripheral signals which modulate food intake and energy expenditure. Gut hormones, such as peptide YY, pancreatic polypeptide, glucagon-like peptide-1, oxyntomodulin, and ghrelin, are modulated by acute food ingestion. In contrast, adiposity signals such as leptin and insulin are implicated in both short- and long-term energy homeostasis. In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3415214/bin/EDR2012-824305.001.gif)
Similar articles
-
The role of gut hormones and the hypothalamus in appetite regulation.Endocr J. 2010;57(5):359-72. doi: 10.1507/endocrj.k10e-077. Epub 2010 Apr 14. Endocr J. 2010. PMID: 20424341 Review.
-
Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids.Nutrients. 2021 Jan 31;13(2):481. doi: 10.3390/nu13020481. Nutrients. 2021. PMID: 33572661 Free PMC article. Review.
-
Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?Int J Obes (Lond). 2016 Apr;40(4):622-32. doi: 10.1038/ijo.2015.220. Epub 2015 Oct 26. Int J Obes (Lond). 2016. PMID: 26499438 Free PMC article. Review.
-
Gastrointestinal hormones regulating appetite.Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1187-209. doi: 10.1098/rstb.2006.1856. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16815798 Free PMC article. Review.
-
Gut hormones as peripheral anti obesity targets.Curr Drug Targets CNS Neurol Disord. 2004 Oct;3(5):379-88. doi: 10.2174/1568007043336950. Curr Drug Targets CNS Neurol Disord. 2004. PMID: 15544446 Review.
Cited by
-
Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients.J Pers Med. 2023 Jun 15;13(6):1003. doi: 10.3390/jpm13061003. J Pers Med. 2023. PMID: 37373992 Free PMC article. Review.
-
Reviewed and updated Algorithm for Genetic Characterization of Syndromic Obesity Phenotypes.Curr Genomics. 2022 Jul 5;23(3):147-162. doi: 10.2174/1389202923666220426093436. Curr Genomics. 2022. PMID: 36777005 Free PMC article. Review.
-
Fat body phospholipid state dictates hunger-driven feeding behavior.Elife. 2022 Oct 6;11:e80282. doi: 10.7554/eLife.80282. Elife. 2022. PMID: 36201241 Free PMC article.
-
A high-fat and high-fructose diet lowers the cecal digesta's weight and short-chain fatty acid level of a Sprague-Dawley rat model.Turk J Med Sci. 2022 Feb;52(1):268-275. doi: 10.3906/sag-1911-14. Epub 2022 Feb 22. Turk J Med Sci. 2022. PMID: 36161602 Free PMC article.
-
Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?Exp Biol Med (Maywood). 2022 Nov;247(21):1898-1906. doi: 10.1177/15353702221113862. Epub 2022 Aug 3. Exp Biol Med (Maywood). 2022. PMID: 35920294 Free PMC article. Clinical Trial.
References
-
- Field AE, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Archives of Internal Medicine. 2001;161(13):1581–1586. - PubMed
-
- Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. The Journal of the American Medical Association. 1999;282(16):1523–1529. - PubMed
-
- Li F, Fisher KJ, Harmer P. Prevalence of overweight and obesity in older U.S. adults: estimates from the 2003 Behavioral Risk Factor Surveillance System survey. Journal of the American Geriatrics Society. 2005;53(4):737–739. - PubMed
-
- Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. The Journal of the American Medical Association. 2003;289(1):76–79. - PubMed
-
- Hagan S, Niswender KD. Neuroendocrine regulation of food intake. Pediatric Blood & Cancer. 2012;58(1):149–153. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical