The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis
- PMID: 22898253
- DOI: 10.1016/j.metabol.2012.07.001
The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis
Abstract
Hypothalamic 5'-adenosine monophosphate-activated protein kinase (AMPK) senses intracellular metabolic stress, i.e., an increase in the cellular AMP:ATP ratio, and integrates diverse hormonal and nutritional signals to restore energy balance. Recent evidence suggests that different nutrients can modulate AMPK activity in the hypothalamus, thereby controlling weight gain through a leptin-independent mechanism. Understanding the mechanisms by which nutrients control hypothalamic AMPK activity is crucial to the development of effective nutritional interventions for the treatment of food intake-related disorders, such as anorexia and obesity. This article highlights the current evidence for the intricate relationship between nutrients and hypothalamic AMPK activity.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Hypothalamic AMP-activated Protein Kinase as a Regulator of Food Intake and Energy Balance.CNS Neurol Disord Drug Targets. 2016;15(8):896-909. doi: 10.2174/1871527315666160815165806. CNS Neurol Disord Drug Targets. 2016. PMID: 27577738 Review.
-
Role of hypothalamic AMP-kinase in food intake regulation.Nutrition. 2008 Sep;24(9):786-90. doi: 10.1016/j.nut.2008.06.002. Nutrition. 2008. PMID: 18725075 Review.
-
AMPK and the neuroendocrine regulation of appetite and energy expenditure.Mol Cell Endocrinol. 2013 Feb 25;366(2):215-23. doi: 10.1016/j.mce.2012.06.012. Epub 2012 Jul 9. Mol Cell Endocrinol. 2013. PMID: 22789749 Review.
-
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance.Int J Mol Sci. 2018 Nov 11;19(11):3552. doi: 10.3390/ijms19113552. Int J Mol Sci. 2018. PMID: 30423881 Free PMC article. Review.
-
Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation.Int J Biochem Cell Biol. 2005 Nov;37(11):2254-9. doi: 10.1016/j.biocel.2005.06.019. Int J Biochem Cell Biol. 2005. PMID: 16085448 Review.
Cited by
-
Diazepam Binding Inhibitor Control of Eu- and Hypoglycemic Patterns of Ventromedial Hypothalamic Nucleus Glucose-Regulatory Signaling.ASN Neuro. 2023 Jan-Dec;15:17590914231214116. doi: 10.1177/17590914231214116. ASN Neuro. 2023. PMID: 38031405 Free PMC article.
-
Differential G Protein-Coupled Estrogen Receptor-1 Regulation of Counter-Regulatory Transmitter Marker and 5'-AMP-Activated Protein Kinase Expression in Ventrolateral versus Dorsomedial Ventromedial Hypothalamic Nucleus.Neuroendocrinology. 2024;114(1):25-41. doi: 10.1159/000533627. Epub 2023 Sep 12. Neuroendocrinology. 2024. PMID: 37699381
-
Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion.ASN Neuro. 2023 Jan-Dec;15:17590914231167230. doi: 10.1177/17590914231167230. ASN Neuro. 2023. PMID: 37194319 Free PMC article.
-
Sex-dimorphic hindbrain lactate regulation of ventromedial hypothalamic nucleus glucoregulatory neuron 5'-AMP-activated protein kinase activity and transmitter marker protein expression.Neuropeptides. 2023 Jun;99:102324. doi: 10.1016/j.npep.2023.102324. Epub 2023 Feb 2. Neuropeptides. 2023. PMID: 36791640 Free PMC article.
-
Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex.Transl Neurosci. 2022 Nov 30;13(1):408-420. doi: 10.1515/tnsci-2022-0259. eCollection 2022 Jan 1. Transl Neurosci. 2022. PMID: 36518559 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
