Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial
- PMID: 22878133
- DOI: 10.1192/bjp.bp.111.104851
Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial
Abstract
Background: There appears to be consensus that patients with only one or two prior depressive episodes do not benefit from treatment with mindfulness-based cognitive therapy (MBCT).
Aims: To investigate whether the effect of MBCT on residual depressive symptoms is contingent on the number of previous depressive episodes (trial number NTR1084).
Method: Currently non-depressed adults with residual depressive symptoms and a history of depression (≤2 prior episodes: n = 71; ≥3 episodes: n = 59) were randomised to MBCT (n = 64) or a waiting list (control: n = 66) in an open-label, randomised controlled trial. The main outcome measured was the reduction in residual depressive symptoms (Hamilton Rating Scale for Depression, HRSD-17).
Results: Mindfulness-based cognitive therapy was superior to the control condition across subgroups (β = -0.56, P<0.001). The interaction between treatment and subgroup was not significant (β = 0.45, P = 0.16).
Conclusions: Mindfulness-based cognitive therapy reduces residual depressive symptoms irrespective of the number of previous episodes of major depression.
Comment in
-
Psychological interventions for difficult-to-treat depression.Br J Psychiatry. 2012 Oct;201(4):260-1. doi: 10.1192/bjp.bp.112.109454. Br J Psychiatry. 2012. PMID: 23028083
Similar articles
-
Adding mindfulness-based cognitive therapy to maintenance antidepressant medication for prevention of relapse/recurrence in major depressive disorder: Randomised controlled trial.J Affect Disord. 2015 Nov 15;187:54-61. doi: 10.1016/j.jad.2015.08.023. Epub 2015 Aug 18. J Affect Disord. 2015. PMID: 26318271 Clinical Trial.
-
Mindfulness-based cognitive therapy: theory and practice.Can J Psychiatry. 2012 Feb;57(2):63-9. doi: 10.1177/070674371205700202. Can J Psychiatry. 2012. PMID: 22340145 Review.
-
The efficacy of mindfulness-based cognitive therapy in recurrent depressed patients with and without a current depressive episode: a randomized controlled trial.Psychol Med. 2012 May;42(5):989-1001. doi: 10.1017/S0033291711002054. Epub 2011 Oct 3. Psychol Med. 2012. PMID: 22017808 Clinical Trial.
-
Mindfulness-based cognitive therapy vs cognitive behaviour therapy as a treatment for non-melancholic depression.J Affect Disord. 2011 Apr;130(1-2):138-44. doi: 10.1016/j.jad.2010.09.027. Epub 2010 Nov 20. J Affect Disord. 2011. PMID: 21093925 Clinical Trial.
-
Mindfulness based cognitive therapy for psychiatric disorders: a systematic review and meta-analysis.Psychiatry Res. 2011 May 30;187(3):441-53. doi: 10.1016/j.psychres.2010.08.011. Epub 2010 Sep 16. Psychiatry Res. 2011. PMID: 20846726 Review.
Cited by
-
Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis.BMJ Ment Health. 2023 Nov;26(1):1-9. doi: 10.1136/bmjment-2023-300827. BMJ Ment Health. 2023. PMID: 37914347 Free PMC article.
-
Individual differences in meditation interventions: A meta-analytic study.Br J Health Psychol. 2022 Sep;27(3):1043-1076. doi: 10.1111/bjhp.12589. Epub 2022 Feb 27. Br J Health Psychol. 2022. PMID: 35224829 Free PMC article.
-
Trait mindfulness is primarily associated with depression and not with fatigue in multiple sclerosis (MS): implications for mindfulness-based interventions.BMC Neurol. 2021 Mar 16;21(1):115. doi: 10.1186/s12883-021-02120-z. BMC Neurol. 2021. PMID: 33726702 Free PMC article.
-
The effectiveness of mindfulness-based cognitive therapy for major depressive disorder: evidence from routine outcome monitoring data.BJPsych Open. 2020 Nov 25;6(6):e144. doi: 10.1192/bjo.2020.118. BJPsych Open. 2020. PMID: 33234183 Free PMC article.
-
Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive Symptoms: A Randomized Clinical Trial.JAMA Psychiatry. 2020 Jun 1;77(6):563-573. doi: 10.1001/jamapsychiatry.2019.4693. JAMA Psychiatry. 2020. PMID: 31995132 Free PMC article. Clinical Trial.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical