Collateral effects of antibiotics on mammalian gut microbiomes
- PMID: 22825498
- PMCID: PMC3466501
- DOI: 10.4161/gmic.21288
Collateral effects of antibiotics on mammalian gut microbiomes
Abstract
Antibiotics are an essential component of the modern lifestyle. They improve our lives by treating disease, preventing disease, and in the case of agricultural animals by improving feed efficiency. However, antibiotic usage is not without collateral effects. The development and spread of antibiotic resistance is the most notorious concern associated with antibiotic use. New technologies have enabled the study of how the microbiota responds to the antibiotic disturbance, including how the community recovers after the antibiotic is removed. One common theme in studies of antibiotic effects is a rapid increase in Escherichia coli followed by a gradual decline. Increases in E. coli are also associated with systemic host stresses, and may be an indicator of ecosystem disturbances of the intestinal microbiota. Moreover, recent studies have shown additional effects mediated by antibiotics on the gut microbiota, such as the stimulation of gene transfer among gut bacteria and the reduction of immune responses in peripheral organs. Querying the microbiota after antibiotic treatment has led to intriguing hypotheses regarding predicting or mitigating unfavorable treatment outcomes. Here we explore the varied effects of antibiotics on human and animal microbiotas.
Similar articles
-
Antibiotics in feed induce prophages in swine fecal microbiomes.mBio. 2011 Nov 29;2(6):e00260-11. doi: 10.1128/mBio.00260-11. Print 2011. mBio. 2011. PMID: 22128350 Free PMC article.
-
'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution.Nat Rev Microbiol. 2013 Apr;11(4):277-84. doi: 10.1038/nrmicro2989. Epub 2013 Mar 11. Nat Rev Microbiol. 2013. PMID: 23474681 Review.
-
Pre-treatment with antibiotics and Escherichia coli to equalize the gut microbiota in conventional mice.Antonie Van Leeuwenhoek. 2015 Jan;107(1):149-56. doi: 10.1007/s10482-014-0312-3. Epub 2014 Oct 31. Antonie Van Leeuwenhoek. 2015. PMID: 25358796
-
The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes.Appl Environ Microbiol. 2016 Oct 27;82(22):6672-6681. doi: 10.1128/AEM.01802-16. Print 2016 Nov 15. Appl Environ Microbiol. 2016. PMID: 27613679 Free PMC article.
-
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma.Gut Microbes. 2013 Mar-Apr;4(2):158-64. doi: 10.4161/gmic.23567. Epub 2013 Jan 18. Gut Microbes. 2013. PMID: 23333861 Free PMC article. Review.
Cited by
-
Factors associated with irritable bowel syndrome and Helicobacter pylori infection: public knowledge and awareness of signs and symptoms.J Int Med Res. 2024 May;52(5):3000605241248041. doi: 10.1177/03000605241248041. J Int Med Res. 2024. PMID: 38775336 Free PMC article.
-
Growth performance, lipid metabolism, and systemic immunity of weaned piglets were altered by buckwheat protein through the modulation of gut microbiota.Mol Genet Genomics. 2024 Feb 27;299(1):15. doi: 10.1007/s00438-024-02103-y. Mol Genet Genomics. 2024. PMID: 38411753
-
Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms.Microorganisms. 2023 Sep 29;11(10):2456. doi: 10.3390/microorganisms11102456. Microorganisms. 2023. PMID: 37894114 Free PMC article.
-
Persistent Dysbiosis, Parasite Rise and Growth Impairment in Aquacultured European Seabass after Oxytetracycline Treatment.Microorganisms. 2023 Sep 13;11(9):2302. doi: 10.3390/microorganisms11092302. Microorganisms. 2023. PMID: 37764146 Free PMC article.
-
Childhood respiratory viral infections and the microbiome.J Allergy Clin Immunol. 2023 Oct;152(4):827-834. doi: 10.1016/j.jaci.2023.08.008. Epub 2023 Aug 20. J Allergy Clin Immunol. 2023. PMID: 37607643 Review.
References
-
- Collignon P, Powers JH, Chiller TM, Aidara-Kane A, Aarestrup FM. World Health Organization ranking of antimicrobials according to their importance in human medicine: A critical step for developing risk management strategies for the use of antimicrobials in food production animals. Clin Infect Dis. 2009;49:132–41. doi: 10.1086/599374. - DOI - PubMed
-
- Food and Drug Administration, Center for Veterinary Medicine The judicious use of medically important antimicrobial drugs in food-producing animals. Guidance for Industry. 2012;209:1–26.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical