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. 2012;7(7):e40097.
doi: 10.1371/journal.pone.0040097. Epub 2012 Jul 10.

The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

Anna-Maija Tolppanen  1 , Adrian Sayers, William D Fraser, Glyn Lewis, Stanley Zammit, Debbie A Lawlor
Affiliations

The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood

Anna-Maija Tolppanen et al. PLoS One. 2012.

Abstract

Background: Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans.

Methods: We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D(3) and 25(OH)D(2)- and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D(3) and 25(OH)D(2) concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome.

Results: Higher 25(OH)D(3) concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D(3) or 25(OH)D(2) concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D.

Conclusions: Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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Figure 1. Flow of participants.
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References

    1. Seamans KM, Cashman KD. Existing and potentially novel functional markers of vitamin D status: A systematic review. Am J Clin Nutr. 2009;89:1997S–2008S. - PubMed
    1. Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, et al. Association of vitamin D deficiency with cognitive impairment in older women: Cross-sectional study. Neurology. 2010;74:27–32. - PubMed
    1. Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, et al. 25-hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74:18–26. - PMC - PubMed
    1. Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, et al. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci. 2009;64:888–895. - PMC - PubMed
    1. Lee DM, Tajar A, Ulubaev A, Pendleton N, O’Neill TW, et al. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older european men. J Neurol Neurosurg Psychiatry. 2009;80:722–729. - PubMed

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