Multivariate multilevel spline models for parallel growth processes: application to weight and mean arterial pressure in pregnancy
- PMID: 22733701
- PMCID: PMC3569877
- DOI: 10.1002/sim.5385
Multivariate multilevel spline models for parallel growth processes: application to weight and mean arterial pressure in pregnancy
Abstract
Growth models are commonly used in life course epidemiology to describe growth trajectories and their determinants or to relate particular patterns of change to later health outcomes. However, methods to analyse relationships between two or more change processes occurring in parallel, in particular to assess evidence for causal influences of change in one variable on subsequent changes in another, are less developed. We discuss linear spline multilevel models with a multivariate response and show how these can be used to relate rates of change in a particular time period in one variable to later rates of change in another variable by using the variances and covariances of individual-level random effects for each of the splines. We describe how regression coefficients can be calculated for these associations and how these can be adjusted for other parameters such as random effect variables relating to baseline values or rates of change in earlier time periods, and compare different methods for calculating the standard errors of these regression coefficients. We also show that these models can equivalently be fitted in the structural equation modelling framework and apply each method to weight and mean arterial pressure changes during pregnancy, obtaining similar results for multilevel and structural equation models. This method improves on the multivariate linear growth models, which have been used previously to model parallel processes because it enables nonlinear patterns of change to be modelled and the temporal sequence of multivariate changes to be determined, with adjustment for change in earlier time periods.
Copyright © 2012 John Wiley & Sons, Ltd.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3569877/bin/sim0031-3147-fig01.gif)
![formula image](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3569877/bin/sim0031-3147-mu0061.jpg)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3569877/bin/sim0031-3147-fig02.gif)
Similar articles
-
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
-
Gestational weight gain below instead of within the guidelines per class of maternal obesity: a systematic review and meta-analysis of obstetrical and neonatal outcomes.Am J Obstet Gynecol MFM. 2022 Sep;4(5):100682. doi: 10.1016/j.ajogmf.2022.100682. Epub 2022 Jun 18. Am J Obstet Gynecol MFM. 2022. PMID: 35728780 Review.
-
Linear spline multilevel models for summarising childhood growth trajectories: A guide to their application using examples from five birth cohorts.Stat Methods Med Res. 2016 Oct;25(5):1854-1874. doi: 10.1177/0962280213503925. Epub 2013 Oct 9. Stat Methods Med Res. 2016. PMID: 24108269 Free PMC article.
-
Impact of the 1990 Hong Kong legislation for restriction on sulfur content in fuel.Res Rep Health Eff Inst. 2012 Aug;(170):5-91. Res Rep Health Eff Inst. 2012. PMID: 23316618
-
Analysis of ambulatory blood pressure monitor data using a hierarchical model incorporating restricted cubic splines and heterogeneous within-subject variances.Stat Med. 2001 Dec 30;20(24):3789-805. doi: 10.1002/sim.1172. Stat Med. 2001. PMID: 11782034
Cited by
-
Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies.BMC Med Res Methodol. 2022 Mar 15;22(1):68. doi: 10.1186/s12874-022-01542-8. BMC Med Res Methodol. 2022. PMID: 35291947 Free PMC article.
-
Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children.BMC Nutr. 2021 Jul 8;7(1):28. doi: 10.1186/s40795-021-00433-3. BMC Nutr. 2021. PMID: 34233762 Free PMC article.
-
Gestational and Postpartum Weight Trajectories Among Women With and Without Asthma.Am J Epidemiol. 2021 May 4;190(5):744-754. doi: 10.1093/aje/kwaa248. Am J Epidemiol. 2021. PMID: 33169142 Free PMC article.
-
Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age.JAMA Netw Open. 2019 Aug 2;2(8):e198918. doi: 10.1001/jamanetworkopen.2019.8918. JAMA Netw Open. 2019. PMID: 31397863 Free PMC article.
-
Gestational weight gain trajectories over pregnancy and their association with maternal diet quality: Results from the PRINCESA cohort.Nutrition. 2019 Sep;65:158-166. doi: 10.1016/j.nut.2019.02.002. Epub 2019 Mar 9. Nutrition. 2019. PMID: 31132630 Free PMC article.
References
-
- Pan H, Goldstein H. Multi-level repeated measures growth modelling using extended spline functions. Statistics in Medicine. 1998;17(23):2755–2770. - PubMed
-
- McCarthy A, Hughes R, Tilling K, Davies D, Davey SG, Ben-Shlomo Y. Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly growth study. American Journal of Clinical Nutrition. 2007;86(4):907–913. - PubMed
-
- Fraser A, Hughes R, McCarthy A, Tilling K, Davies D, Rumley A, Lowe GDO, Davey SG, Ben-Shlomo Y. Early life growth and hemostatic factors. American Journal of Epidemiology. 2008;168(2):179–187. - PubMed
-
- Ben-Shlomo Y, McCarthy A, Hughes R, Tilling K, Davies D, Davey SG. Immediate postnatal growth is associated with blood pressure in young adulthood - The Barry Caerphilly growth study. Hypertension. 2008;52(4):638–644. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical